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A Pictorial Exploration of Mammary Paget Disease: Insights and Perspectives

SIMPLE SUMMARY: This review provides a comprehensive overview of mammary Paget disease (MPD) from its historical origins to the current diagnostic and treatment strategies while also exploring promising avenues for future advancements in the field. With improved understanding and ongoing research ef...

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Autores principales: Mariano, Luciano, Nicosia, Luca, Pupo, Davide, Olivieri, Antonia Maria, Scolari, Sofia, Pesapane, Filippo, Latronico, Antuono, Bozzini, Anna Carla, Fusco, Nicola, Blanco, Marta Cruz, Mazzarol, Giovanni, Corso, Giovanni, Galimberti, Viviana Enrica, Venturini, Massimo, Pizzamiglio, Maria, Cassano, Enrico
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10650713/
https://www.ncbi.nlm.nih.gov/pubmed/37958452
http://dx.doi.org/10.3390/cancers15215276
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author Mariano, Luciano
Nicosia, Luca
Pupo, Davide
Olivieri, Antonia Maria
Scolari, Sofia
Pesapane, Filippo
Latronico, Antuono
Bozzini, Anna Carla
Fusco, Nicola
Blanco, Marta Cruz
Mazzarol, Giovanni
Corso, Giovanni
Galimberti, Viviana Enrica
Venturini, Massimo
Pizzamiglio, Maria
Cassano, Enrico
author_facet Mariano, Luciano
Nicosia, Luca
Pupo, Davide
Olivieri, Antonia Maria
Scolari, Sofia
Pesapane, Filippo
Latronico, Antuono
Bozzini, Anna Carla
Fusco, Nicola
Blanco, Marta Cruz
Mazzarol, Giovanni
Corso, Giovanni
Galimberti, Viviana Enrica
Venturini, Massimo
Pizzamiglio, Maria
Cassano, Enrico
author_sort Mariano, Luciano
collection PubMed
description SIMPLE SUMMARY: This review provides a comprehensive overview of mammary Paget disease (MPD) from its historical origins to the current diagnostic and treatment strategies while also exploring promising avenues for future advancements in the field. With improved understanding and ongoing research efforts, we aim to enhance the prognosis and quality of life for individuals affected by this relatively uncommon condition. ABSTRACT: Mammary Paget disease (MPD) is a rare condition primarily affecting adult women, characterized by unilateral skin changes in the nipple–areolar complex (NAC) and frequently associated with underlying breast carcinoma. Histologically, MPD is identified by large intraepidermal epithelial cells (Paget cells) with distinct characteristics. Immunohistochemical profiles aid in distinguishing MPD from other skin conditions. Clinical evaluation and imaging techniques, including magnetic resonance imaging (MRI), are recommended if MPD is suspected, although definitive diagnosis always requires histological examination. This review delves into the historical context, epidemiology, pathogenesis, clinical manifestations, and diagnosis of MPD, emphasizing the need for early detection. The classification of MPD based on pathogenesis is explored, shedding light on its varied presentations. Treatment options, including mastectomy and breast-conserving surgery, are discussed with clear guidelines for different scenarios. Adjuvant therapies are considered, particularly in cases with underlying breast cancer. Prognostic factors are outlined, underlining the importance of early intervention. Looking to the future, emerging techniques, like liquid biopsy, new immunohistochemical and molecular markers, and artificial intelligence-based image analysis, hold the potential to transform MPD diagnosis and treatment. These innovations offer hope for early detection and improved patient care, though validation through large-scale clinical trials is needed.
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spelling pubmed-106507132023-11-03 A Pictorial Exploration of Mammary Paget Disease: Insights and Perspectives Mariano, Luciano Nicosia, Luca Pupo, Davide Olivieri, Antonia Maria Scolari, Sofia Pesapane, Filippo Latronico, Antuono Bozzini, Anna Carla Fusco, Nicola Blanco, Marta Cruz Mazzarol, Giovanni Corso, Giovanni Galimberti, Viviana Enrica Venturini, Massimo Pizzamiglio, Maria Cassano, Enrico Cancers (Basel) Review SIMPLE SUMMARY: This review provides a comprehensive overview of mammary Paget disease (MPD) from its historical origins to the current diagnostic and treatment strategies while also exploring promising avenues for future advancements in the field. With improved understanding and ongoing research efforts, we aim to enhance the prognosis and quality of life for individuals affected by this relatively uncommon condition. ABSTRACT: Mammary Paget disease (MPD) is a rare condition primarily affecting adult women, characterized by unilateral skin changes in the nipple–areolar complex (NAC) and frequently associated with underlying breast carcinoma. Histologically, MPD is identified by large intraepidermal epithelial cells (Paget cells) with distinct characteristics. Immunohistochemical profiles aid in distinguishing MPD from other skin conditions. Clinical evaluation and imaging techniques, including magnetic resonance imaging (MRI), are recommended if MPD is suspected, although definitive diagnosis always requires histological examination. This review delves into the historical context, epidemiology, pathogenesis, clinical manifestations, and diagnosis of MPD, emphasizing the need for early detection. The classification of MPD based on pathogenesis is explored, shedding light on its varied presentations. Treatment options, including mastectomy and breast-conserving surgery, are discussed with clear guidelines for different scenarios. Adjuvant therapies are considered, particularly in cases with underlying breast cancer. Prognostic factors are outlined, underlining the importance of early intervention. Looking to the future, emerging techniques, like liquid biopsy, new immunohistochemical and molecular markers, and artificial intelligence-based image analysis, hold the potential to transform MPD diagnosis and treatment. These innovations offer hope for early detection and improved patient care, though validation through large-scale clinical trials is needed. MDPI 2023-11-03 /pmc/articles/PMC10650713/ /pubmed/37958452 http://dx.doi.org/10.3390/cancers15215276 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Mariano, Luciano
Nicosia, Luca
Pupo, Davide
Olivieri, Antonia Maria
Scolari, Sofia
Pesapane, Filippo
Latronico, Antuono
Bozzini, Anna Carla
Fusco, Nicola
Blanco, Marta Cruz
Mazzarol, Giovanni
Corso, Giovanni
Galimberti, Viviana Enrica
Venturini, Massimo
Pizzamiglio, Maria
Cassano, Enrico
A Pictorial Exploration of Mammary Paget Disease: Insights and Perspectives
title A Pictorial Exploration of Mammary Paget Disease: Insights and Perspectives
title_full A Pictorial Exploration of Mammary Paget Disease: Insights and Perspectives
title_fullStr A Pictorial Exploration of Mammary Paget Disease: Insights and Perspectives
title_full_unstemmed A Pictorial Exploration of Mammary Paget Disease: Insights and Perspectives
title_short A Pictorial Exploration of Mammary Paget Disease: Insights and Perspectives
title_sort pictorial exploration of mammary paget disease: insights and perspectives
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10650713/
https://www.ncbi.nlm.nih.gov/pubmed/37958452
http://dx.doi.org/10.3390/cancers15215276
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