Resistance to 2-Hydroxy-Flutamide in Prostate Cancer Cells Is Associated with the Downregulation of Phosphatidylcholine Biosynthesis and Epigenetic Modifications

In this study, we examined the metabolic adaptations of a chemoresistant prostate cancer cell line in comparison to a sensitive cell line. We utilized prostate cancer LNCaP cells and subjected them to a stepwise increase in the antiandrogen 2-hydroxy-flutamide (FLU) concentration to generate a FLU-r...

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Detalles Bibliográficos
Autores principales: Mora-Rodríguez, José María, Sánchez, Belén G., Sebastián-Martín, Alba, Díaz-Yuste, Alba, Sánchez-Chapado, Manuel, Palacín, Ana María, Sánchez-Rodríguez, Carlos, Bort, Alicia, Díaz-Laviada, Inés
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10650717/
https://www.ncbi.nlm.nih.gov/pubmed/37958610
http://dx.doi.org/10.3390/ijms242115626

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10650717/
https://www.ncbi.nlm.nih.gov/pubmed/37958610
http://dx.doi.org/10.3390/ijms242115626

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