DNA Methylation and Telomeres—Their Impact on the Occurrence of Atrial Fibrillation during Cardiac Aging

Atrial fibrillation (AF) is the most common arrhythmia in humans. AF is characterized by irregular and increased atrial muscle activation. This high-frequency activation obliterates the synchronous work of the atria and ventricles, reducing myocardial performance, which can lead to severe heart fail...

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Autores principales: Grzeczka, Arkadiusz, Graczyk, Szymon, Kordowitzki, Pawel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10650750/
https://www.ncbi.nlm.nih.gov/pubmed/37958686
http://dx.doi.org/10.3390/ijms242115699
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author Grzeczka, Arkadiusz
Graczyk, Szymon
Kordowitzki, Pawel
author_facet Grzeczka, Arkadiusz
Graczyk, Szymon
Kordowitzki, Pawel
author_sort Grzeczka, Arkadiusz
collection PubMed
description Atrial fibrillation (AF) is the most common arrhythmia in humans. AF is characterized by irregular and increased atrial muscle activation. This high-frequency activation obliterates the synchronous work of the atria and ventricles, reducing myocardial performance, which can lead to severe heart failure or stroke. The risk of developing atrial fibrillation depends largely on the patient’s history. Cardiovascular diseases are considered aging-related pathologies; therefore, deciphering the role of telomeres and DNA methylation (mDNA), two hallmarks of aging, is likely to contribute to a better understanding and prophylaxis of AF. In honor of Prof. Elizabeth Blackburn’s 75th birthday, we dedicate this review to the discovery of telomeres and her contribution to research on aging.
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spelling pubmed-106507502023-10-28 DNA Methylation and Telomeres—Their Impact on the Occurrence of Atrial Fibrillation during Cardiac Aging Grzeczka, Arkadiusz Graczyk, Szymon Kordowitzki, Pawel Int J Mol Sci Review Atrial fibrillation (AF) is the most common arrhythmia in humans. AF is characterized by irregular and increased atrial muscle activation. This high-frequency activation obliterates the synchronous work of the atria and ventricles, reducing myocardial performance, which can lead to severe heart failure or stroke. The risk of developing atrial fibrillation depends largely on the patient’s history. Cardiovascular diseases are considered aging-related pathologies; therefore, deciphering the role of telomeres and DNA methylation (mDNA), two hallmarks of aging, is likely to contribute to a better understanding and prophylaxis of AF. In honor of Prof. Elizabeth Blackburn’s 75th birthday, we dedicate this review to the discovery of telomeres and her contribution to research on aging. MDPI 2023-10-28 /pmc/articles/PMC10650750/ /pubmed/37958686 http://dx.doi.org/10.3390/ijms242115699 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Grzeczka, Arkadiusz
Graczyk, Szymon
Kordowitzki, Pawel
DNA Methylation and Telomeres—Their Impact on the Occurrence of Atrial Fibrillation during Cardiac Aging
title DNA Methylation and Telomeres—Their Impact on the Occurrence of Atrial Fibrillation during Cardiac Aging
title_full DNA Methylation and Telomeres—Their Impact on the Occurrence of Atrial Fibrillation during Cardiac Aging
title_fullStr DNA Methylation and Telomeres—Their Impact on the Occurrence of Atrial Fibrillation during Cardiac Aging
title_full_unstemmed DNA Methylation and Telomeres—Their Impact on the Occurrence of Atrial Fibrillation during Cardiac Aging
title_short DNA Methylation and Telomeres—Their Impact on the Occurrence of Atrial Fibrillation during Cardiac Aging
title_sort dna methylation and telomeres—their impact on the occurrence of atrial fibrillation during cardiac aging
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10650750/
https://www.ncbi.nlm.nih.gov/pubmed/37958686
http://dx.doi.org/10.3390/ijms242115699
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