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High-Frequency Ultrasound Imaging to Distinguish High-Risk and Low-Risk Dermatofibromas
Background: Dermatofibroma has various pathological classifications, some of which pose a risk of recurrence and metastasis. Distinguishing these high-risk dermatofibromas based on appearance alone can be challenging. Therefore, high-frequency ultrasound may provide additional internal information o...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10650765/ https://www.ncbi.nlm.nih.gov/pubmed/37958200 http://dx.doi.org/10.3390/diagnostics13213305 |
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author | Li, Danhua Yang, Feiyue Zhao, Yang Wang, Qiao Ren, Weiwei Sun, Liping Shan, Dandan Qin, Chuan |
author_facet | Li, Danhua Yang, Feiyue Zhao, Yang Wang, Qiao Ren, Weiwei Sun, Liping Shan, Dandan Qin, Chuan |
author_sort | Li, Danhua |
collection | PubMed |
description | Background: Dermatofibroma has various pathological classifications, some of which pose a risk of recurrence and metastasis. Distinguishing these high-risk dermatofibromas based on appearance alone can be challenging. Therefore, high-frequency ultrasound may provide additional internal information on these lesions, helping to identify high-risk and low-risk dermatofibroma early. Methods: In this retrospective study, 50 lesions were analyzed to explore the correlation between clinical and high-frequency ultrasound features and dermatofibroma risk level. Based on their pathological features, the lesions were divided into high-risk (n = 17) and low-risk (n = 33) groups. Subsequently, an identification model based on significant high-frequency ultrasound features was developed. Results: Significant differences were observed in the thickness, shape, internal echogenicity, stratum basal, and Doppler vascular patterns between the high-risk and low-risk groups. The median lesion thickness for the high-risk dermatofibroma group was 4.1 mm (IQR: 3.2–6.1 mm), while it was 3.1 mm (IQR: 1.3–4.2 mm) for the low-risk dermatofibroma group. In the high-risk dermatofibroma group, irregular morphology was predominant (70.6%, 12/17), the most common being dermis-to-subcutaneous soft tissue penetration (64.7%, 11/17), and heterogenous internal echogenicity was observed in the majority of cases (76.5%, 13/17). On the other hand, regular morphology was more prevalent in the low-risk dermatofibroma group (78.8%, 26/33), primarily limited to the dermis layer (78.8%, 26/33), with homogeneous internal echogenicity also being prevalent in the majority of cases (81.8%, 27/33). Regarding the Doppler vascularity pattern, 69.7% (23/33) of low-risk dermatofibromas had no blood flow, while 64.7% (11/17) of high-risk dermatofibromas had blood flow. Conclusion: High-frequency ultrasound is crucial in distinguishing high-risk and low-risk dermatofibromas, making it invaluable for clinical management. |
format | Online Article Text |
id | pubmed-10650765 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-106507652023-10-25 High-Frequency Ultrasound Imaging to Distinguish High-Risk and Low-Risk Dermatofibromas Li, Danhua Yang, Feiyue Zhao, Yang Wang, Qiao Ren, Weiwei Sun, Liping Shan, Dandan Qin, Chuan Diagnostics (Basel) Article Background: Dermatofibroma has various pathological classifications, some of which pose a risk of recurrence and metastasis. Distinguishing these high-risk dermatofibromas based on appearance alone can be challenging. Therefore, high-frequency ultrasound may provide additional internal information on these lesions, helping to identify high-risk and low-risk dermatofibroma early. Methods: In this retrospective study, 50 lesions were analyzed to explore the correlation between clinical and high-frequency ultrasound features and dermatofibroma risk level. Based on their pathological features, the lesions were divided into high-risk (n = 17) and low-risk (n = 33) groups. Subsequently, an identification model based on significant high-frequency ultrasound features was developed. Results: Significant differences were observed in the thickness, shape, internal echogenicity, stratum basal, and Doppler vascular patterns between the high-risk and low-risk groups. The median lesion thickness for the high-risk dermatofibroma group was 4.1 mm (IQR: 3.2–6.1 mm), while it was 3.1 mm (IQR: 1.3–4.2 mm) for the low-risk dermatofibroma group. In the high-risk dermatofibroma group, irregular morphology was predominant (70.6%, 12/17), the most common being dermis-to-subcutaneous soft tissue penetration (64.7%, 11/17), and heterogenous internal echogenicity was observed in the majority of cases (76.5%, 13/17). On the other hand, regular morphology was more prevalent in the low-risk dermatofibroma group (78.8%, 26/33), primarily limited to the dermis layer (78.8%, 26/33), with homogeneous internal echogenicity also being prevalent in the majority of cases (81.8%, 27/33). Regarding the Doppler vascularity pattern, 69.7% (23/33) of low-risk dermatofibromas had no blood flow, while 64.7% (11/17) of high-risk dermatofibromas had blood flow. Conclusion: High-frequency ultrasound is crucial in distinguishing high-risk and low-risk dermatofibromas, making it invaluable for clinical management. MDPI 2023-10-25 /pmc/articles/PMC10650765/ /pubmed/37958200 http://dx.doi.org/10.3390/diagnostics13213305 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Li, Danhua Yang, Feiyue Zhao, Yang Wang, Qiao Ren, Weiwei Sun, Liping Shan, Dandan Qin, Chuan High-Frequency Ultrasound Imaging to Distinguish High-Risk and Low-Risk Dermatofibromas |
title | High-Frequency Ultrasound Imaging to Distinguish High-Risk and Low-Risk Dermatofibromas |
title_full | High-Frequency Ultrasound Imaging to Distinguish High-Risk and Low-Risk Dermatofibromas |
title_fullStr | High-Frequency Ultrasound Imaging to Distinguish High-Risk and Low-Risk Dermatofibromas |
title_full_unstemmed | High-Frequency Ultrasound Imaging to Distinguish High-Risk and Low-Risk Dermatofibromas |
title_short | High-Frequency Ultrasound Imaging to Distinguish High-Risk and Low-Risk Dermatofibromas |
title_sort | high-frequency ultrasound imaging to distinguish high-risk and low-risk dermatofibromas |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10650765/ https://www.ncbi.nlm.nih.gov/pubmed/37958200 http://dx.doi.org/10.3390/diagnostics13213305 |
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