Combined Multiplexed Phage Display, High-Throughput Sequencing, and Functional Assays as a Platform for Identifying Modulatory VHHs Targeting the FSHR

Developing modulatory antibodies against G protein-coupled receptors is challenging. In this study, we targeted the follicle-stimulating hormone receptor (FSHR), a significant regulator of reproduction, with variable domains of heavy chain-only antibodies (VHHs). We built two immune VHH libraries an...

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Detalles Bibliográficos
Autores principales: Zehnaker, Anielka, Vallet, Amandine, Gourdon, Juliette, Sarti, Caterina, Jugnarain, Vinesh, Haj Hassan, Maya, Mathias, Laetitia, Gauthier, Camille, Raynaud, Pauline, Boulo, Thomas, Beauclair, Linda, Bigot, Yves, Casarini, Livio, Crépieux, Pascale, Poupon, Anne, Piégu, Benoît, Jean-Alphonse, Frédéric, Bruneau, Gilles, Reiter, Éric
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10650796/
https://www.ncbi.nlm.nih.gov/pubmed/37958944
http://dx.doi.org/10.3390/ijms242115961

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