LAIR-1 agonism as a therapy for acute myeloid leukemia

Effective eradication of leukemic stem cells (LSCs) remains the greatest challenge in treating acute myeloid leukemia (AML). The immune receptor LAIR-1 has been shown to regulate LSC survival; however, the therapeutic potential of this pathway remains unexplored. We developed a therapeutic LAIR-1 ag...

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Detalles Bibliográficos
Autores principales: Lovewell, Rustin R., Hong, Junshik, Kundu, Subhadip, Fielder, Carly M., Hu, Qianni, Kim, Kwang Woon, Ramsey, Haley E., Gorska, Agnieszka E., Fuller, Londa S., Tian, Linjie, Kothari, Priyanka, Paucarmayta, Ana, Mason, Emily F., Meza, Ingrid, Manzanarez, Yanira, Bosiacki, Jason, Maloveste, Karla, Mitchell, Ngan, Barbu, Emilia A., Morawski, Aaron, Maloveste, Sebastien, Cusumano, Zac, Patel, Shashank J., Savona, Michael R., Langermann, Solomon, Myint, Han, Flies, Dallas B., Kim, Tae Kon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10650974/
https://www.ncbi.nlm.nih.gov/pubmed/37966113
http://dx.doi.org/10.1172/JCI169519

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