Pro/con clinical debate: It is acceptable to stop large multicentre randomized controlled trials at interim analysis for futility

A few recent, large, well-publicized trials in critical care medicine have been stopped for futility. In the critical care setting, stopping for futility means that independent review committees have elected to stop the trial early – based on predetermined rules – since the likelihood of finding a t...

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Detalles Bibliográficos
Autores principales: Schoenfeld, David A, Meade, Maureen O
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2005
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1065108/
https://www.ncbi.nlm.nih.gov/pubmed/15693981
http://dx.doi.org/10.1186/cc3013
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author Schoenfeld, David A
Meade, Maureen O
author_facet Schoenfeld, David A
Meade, Maureen O
author_sort Schoenfeld, David A
collection PubMed
description A few recent, large, well-publicized trials in critical care medicine have been stopped for futility. In the critical care setting, stopping for futility means that independent review committees have elected to stop the trial early – based on predetermined rules – since the likelihood of finding a treatment effect is low. For bedside clinicians the idea of futility in a clinical trial can be confusing. In the present article, two experts in the conduct of clinical trials debate the role of futility-stopping rules.
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spelling pubmed-10651082005-03-16 Pro/con clinical debate: It is acceptable to stop large multicentre randomized controlled trials at interim analysis for futility Schoenfeld, David A Meade, Maureen O Crit Care Review A few recent, large, well-publicized trials in critical care medicine have been stopped for futility. In the critical care setting, stopping for futility means that independent review committees have elected to stop the trial early – based on predetermined rules – since the likelihood of finding a treatment effect is low. For bedside clinicians the idea of futility in a clinical trial can be confusing. In the present article, two experts in the conduct of clinical trials debate the role of futility-stopping rules. BioMed Central 2005 2004-12-09 /pmc/articles/PMC1065108/ /pubmed/15693981 http://dx.doi.org/10.1186/cc3013 Text en Copyright © 2004 BioMed Central Ltd
spellingShingle Review
Schoenfeld, David A
Meade, Maureen O
Pro/con clinical debate: It is acceptable to stop large multicentre randomized controlled trials at interim analysis for futility
title Pro/con clinical debate: It is acceptable to stop large multicentre randomized controlled trials at interim analysis for futility
title_full Pro/con clinical debate: It is acceptable to stop large multicentre randomized controlled trials at interim analysis for futility
title_fullStr Pro/con clinical debate: It is acceptable to stop large multicentre randomized controlled trials at interim analysis for futility
title_full_unstemmed Pro/con clinical debate: It is acceptable to stop large multicentre randomized controlled trials at interim analysis for futility
title_short Pro/con clinical debate: It is acceptable to stop large multicentre randomized controlled trials at interim analysis for futility
title_sort pro/con clinical debate: it is acceptable to stop large multicentre randomized controlled trials at interim analysis for futility
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1065108/
https://www.ncbi.nlm.nih.gov/pubmed/15693981
http://dx.doi.org/10.1186/cc3013
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