Expression of the transcription factor Klf6 by thymic epithelial cells is required for thymus development

Thymic epithelial cells (TEC) control T cell development and play essential roles in establishing self-tolerance. By using Foxn1-Cre–driven ablation of Klf6 gene in TEC, we identified Klf6 as a critical factor in TEC development. Klf6 deficiency resulted in a hypoplastic thymus—evident from fetal st...

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Detalles Bibliográficos
Autores principales: Malin, Justin, Martinez-Ruiz, Gustavo Ulises, Zhao, Yongge, Shissler, Susannah C., Cowan, Jennifer E., Ding, Yi, Morales-Sanchez, Abigail, Ishikawa, Masaki, Lavaert, Marieke, Das, Arundhoti, Butcher, Donna, Warner, Andrew C., Kallarakal, Melissa, Chen, Jingqiu, Kedei, Noemi, Kelly, Michael, Brinster, Lauren R., Allman, David, Bhandoola, Avinash
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10651122/
https://www.ncbi.nlm.nih.gov/pubmed/37967174
http://dx.doi.org/10.1126/sciadv.adg8126

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