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Window into the mind: Advanced handheld spectroscopic eye-safe technology for point-of-care neurodiagnostic

Traumatic brain injury (TBI), a major cause of morbidity and mortality worldwide, is hard to diagnose at the point of care with patients often exhibiting no clinical symptoms. There is an urgent need for rapid point-of-care diagnostics to enable timely intervention. We have developed a technology fo...

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Autores principales: Banbury, Carl, Harris, Georgia, Clancy, Michael, Blanch, Richard J., Rickard, Jonathan James Stanley, Goldberg Oppenheimer, Pola
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10651125/
https://www.ncbi.nlm.nih.gov/pubmed/37967190
http://dx.doi.org/10.1126/sciadv.adg5431
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author Banbury, Carl
Harris, Georgia
Clancy, Michael
Blanch, Richard J.
Rickard, Jonathan James Stanley
Goldberg Oppenheimer, Pola
author_facet Banbury, Carl
Harris, Georgia
Clancy, Michael
Blanch, Richard J.
Rickard, Jonathan James Stanley
Goldberg Oppenheimer, Pola
author_sort Banbury, Carl
collection PubMed
description Traumatic brain injury (TBI), a major cause of morbidity and mortality worldwide, is hard to diagnose at the point of care with patients often exhibiting no clinical symptoms. There is an urgent need for rapid point-of-care diagnostics to enable timely intervention. We have developed a technology for rapid acquisition of molecular fingerprints of TBI biochemistry to safely measure proxies for cerebral injury through the eye, providing a path toward noninvasive point-of-care neurodiagnostics using simultaneous Raman spectroscopy and fundus imaging of the neuroretina. Detection of endogenous neuromarkers in porcine eyes’ posterior revealed enhancement of high–wave number bands, clearly distinguishing TBI and healthy cohorts, classified via artificial neural network algorithm for automated data interpretation. Clinically, translating into reduced specialist support, this markedly improves the speed of diagnosis. Designed as a hand-held cost-effective technology, it can allow clinicians to rapidly assess TBI at the point of care and identify long-term changes in brain biochemistry in acute or chronic neurodiseases.
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spelling pubmed-106511252023-11-15 Window into the mind: Advanced handheld spectroscopic eye-safe technology for point-of-care neurodiagnostic Banbury, Carl Harris, Georgia Clancy, Michael Blanch, Richard J. Rickard, Jonathan James Stanley Goldberg Oppenheimer, Pola Sci Adv Neuroscience Traumatic brain injury (TBI), a major cause of morbidity and mortality worldwide, is hard to diagnose at the point of care with patients often exhibiting no clinical symptoms. There is an urgent need for rapid point-of-care diagnostics to enable timely intervention. We have developed a technology for rapid acquisition of molecular fingerprints of TBI biochemistry to safely measure proxies for cerebral injury through the eye, providing a path toward noninvasive point-of-care neurodiagnostics using simultaneous Raman spectroscopy and fundus imaging of the neuroretina. Detection of endogenous neuromarkers in porcine eyes’ posterior revealed enhancement of high–wave number bands, clearly distinguishing TBI and healthy cohorts, classified via artificial neural network algorithm for automated data interpretation. Clinically, translating into reduced specialist support, this markedly improves the speed of diagnosis. Designed as a hand-held cost-effective technology, it can allow clinicians to rapidly assess TBI at the point of care and identify long-term changes in brain biochemistry in acute or chronic neurodiseases. American Association for the Advancement of Science 2023-11-15 /pmc/articles/PMC10651125/ /pubmed/37967190 http://dx.doi.org/10.1126/sciadv.adg5431 Text en Copyright © 2023 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution License 4.0 (CC BY). https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution license (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Neuroscience
Banbury, Carl
Harris, Georgia
Clancy, Michael
Blanch, Richard J.
Rickard, Jonathan James Stanley
Goldberg Oppenheimer, Pola
Window into the mind: Advanced handheld spectroscopic eye-safe technology for point-of-care neurodiagnostic
title Window into the mind: Advanced handheld spectroscopic eye-safe technology for point-of-care neurodiagnostic
title_full Window into the mind: Advanced handheld spectroscopic eye-safe technology for point-of-care neurodiagnostic
title_fullStr Window into the mind: Advanced handheld spectroscopic eye-safe technology for point-of-care neurodiagnostic
title_full_unstemmed Window into the mind: Advanced handheld spectroscopic eye-safe technology for point-of-care neurodiagnostic
title_short Window into the mind: Advanced handheld spectroscopic eye-safe technology for point-of-care neurodiagnostic
title_sort window into the mind: advanced handheld spectroscopic eye-safe technology for point-of-care neurodiagnostic
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10651125/
https://www.ncbi.nlm.nih.gov/pubmed/37967190
http://dx.doi.org/10.1126/sciadv.adg5431
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