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Window into the mind: Advanced handheld spectroscopic eye-safe technology for point-of-care neurodiagnostic
Traumatic brain injury (TBI), a major cause of morbidity and mortality worldwide, is hard to diagnose at the point of care with patients often exhibiting no clinical symptoms. There is an urgent need for rapid point-of-care diagnostics to enable timely intervention. We have developed a technology fo...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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American Association for the Advancement of Science
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10651125/ https://www.ncbi.nlm.nih.gov/pubmed/37967190 http://dx.doi.org/10.1126/sciadv.adg5431 |
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author | Banbury, Carl Harris, Georgia Clancy, Michael Blanch, Richard J. Rickard, Jonathan James Stanley Goldberg Oppenheimer, Pola |
author_facet | Banbury, Carl Harris, Georgia Clancy, Michael Blanch, Richard J. Rickard, Jonathan James Stanley Goldberg Oppenheimer, Pola |
author_sort | Banbury, Carl |
collection | PubMed |
description | Traumatic brain injury (TBI), a major cause of morbidity and mortality worldwide, is hard to diagnose at the point of care with patients often exhibiting no clinical symptoms. There is an urgent need for rapid point-of-care diagnostics to enable timely intervention. We have developed a technology for rapid acquisition of molecular fingerprints of TBI biochemistry to safely measure proxies for cerebral injury through the eye, providing a path toward noninvasive point-of-care neurodiagnostics using simultaneous Raman spectroscopy and fundus imaging of the neuroretina. Detection of endogenous neuromarkers in porcine eyes’ posterior revealed enhancement of high–wave number bands, clearly distinguishing TBI and healthy cohorts, classified via artificial neural network algorithm for automated data interpretation. Clinically, translating into reduced specialist support, this markedly improves the speed of diagnosis. Designed as a hand-held cost-effective technology, it can allow clinicians to rapidly assess TBI at the point of care and identify long-term changes in brain biochemistry in acute or chronic neurodiseases. |
format | Online Article Text |
id | pubmed-10651125 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | American Association for the Advancement of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-106511252023-11-15 Window into the mind: Advanced handheld spectroscopic eye-safe technology for point-of-care neurodiagnostic Banbury, Carl Harris, Georgia Clancy, Michael Blanch, Richard J. Rickard, Jonathan James Stanley Goldberg Oppenheimer, Pola Sci Adv Neuroscience Traumatic brain injury (TBI), a major cause of morbidity and mortality worldwide, is hard to diagnose at the point of care with patients often exhibiting no clinical symptoms. There is an urgent need for rapid point-of-care diagnostics to enable timely intervention. We have developed a technology for rapid acquisition of molecular fingerprints of TBI biochemistry to safely measure proxies for cerebral injury through the eye, providing a path toward noninvasive point-of-care neurodiagnostics using simultaneous Raman spectroscopy and fundus imaging of the neuroretina. Detection of endogenous neuromarkers in porcine eyes’ posterior revealed enhancement of high–wave number bands, clearly distinguishing TBI and healthy cohorts, classified via artificial neural network algorithm for automated data interpretation. Clinically, translating into reduced specialist support, this markedly improves the speed of diagnosis. Designed as a hand-held cost-effective technology, it can allow clinicians to rapidly assess TBI at the point of care and identify long-term changes in brain biochemistry in acute or chronic neurodiseases. American Association for the Advancement of Science 2023-11-15 /pmc/articles/PMC10651125/ /pubmed/37967190 http://dx.doi.org/10.1126/sciadv.adg5431 Text en Copyright © 2023 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution License 4.0 (CC BY). https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution license (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Neuroscience Banbury, Carl Harris, Georgia Clancy, Michael Blanch, Richard J. Rickard, Jonathan James Stanley Goldberg Oppenheimer, Pola Window into the mind: Advanced handheld spectroscopic eye-safe technology for point-of-care neurodiagnostic |
title | Window into the mind: Advanced handheld spectroscopic eye-safe technology for point-of-care neurodiagnostic |
title_full | Window into the mind: Advanced handheld spectroscopic eye-safe technology for point-of-care neurodiagnostic |
title_fullStr | Window into the mind: Advanced handheld spectroscopic eye-safe technology for point-of-care neurodiagnostic |
title_full_unstemmed | Window into the mind: Advanced handheld spectroscopic eye-safe technology for point-of-care neurodiagnostic |
title_short | Window into the mind: Advanced handheld spectroscopic eye-safe technology for point-of-care neurodiagnostic |
title_sort | window into the mind: advanced handheld spectroscopic eye-safe technology for point-of-care neurodiagnostic |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10651125/ https://www.ncbi.nlm.nih.gov/pubmed/37967190 http://dx.doi.org/10.1126/sciadv.adg5431 |
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