Salvage therapy expands highly cytotoxic and metabolically fit resilient CD8(+) T cells via ME1 up-regulation

Patients with advanced cancers who either do not experience initial response to or progress while on immune checkpoint inhibitors (ICIs) receive salvage radiotherapy to reduce tumor burden and tumor-related symptoms. Occasionally, some patients experience substantial global tumor regression with a r...

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Detalles Bibliográficos
Autores principales: Gicobi, Joanina K., Mao, Zhiming, DeFranco, Grace, Hirdler, Jacob B., Li, Ying, Vianzon, Vianca V., Dellacecca, Emilia R., Hsu, Michelle A., Barham, Whitney, Yan, Yiyi, Mansfield, Aaron S., Lin, Yi, Wu, Xiaosheng, Hitosugi, Taro, Owen, Dawn, Grams, Michael P., Orme, Jacob J., Lucien, Fabrice, Zeng, Hu, Park, Sean S., Dong, Haidong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10651128/
https://www.ncbi.nlm.nih.gov/pubmed/37967193
http://dx.doi.org/10.1126/sciadv.adi2414

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