Two-color coincidence single-molecule pulldown for the specific detection of disease-associated protein aggregates

Protein misfolding and aggregation is a characteristic of many neurodegenerative disorders, including Alzheimer’s and Parkinson’s disease. The oligomers generated during aggregation are likely involved in disease pathogenesis and present promising biomarker candidates. However, owing to their small...

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Detalles Bibliográficos
Autores principales: Saleeb, Rebecca S., Leighton, Craig, Lee, Ji-Eun, O’Shaughnessy, Judi, Jeacock, Kiani, Chappard, Alexandre, Cumberland, Robyn, Zhao, Tianxiao, Ball, Sarah R., Sunde, Margaret, Clarke, David J., Piché, Kristin, McPhail, Jacob A., Louwrier, Ariel, Angers, Rachel, Gandhi, Sonia, Downey, Patrick, Kunath, Tilo, Horrocks, Mathew H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10651132/
https://www.ncbi.nlm.nih.gov/pubmed/37967183
http://dx.doi.org/10.1126/sciadv.adi7359

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