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Conscious processing of global and local auditory irregularities causes differentiated heartbeat-evoked responses
Recent research suggests that brain-heart interactions are associated with perceptual and self-consciousness. In this line, the neural responses to visceral inputs have been hypothesized to play a leading role in shaping our subjective experience. This study aims to investigate whether the contextua...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10651171/ https://www.ncbi.nlm.nih.gov/pubmed/37888955 http://dx.doi.org/10.7554/eLife.75352 |
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author | Candia-Rivera, Diego Raimondo, Federico Pérez, Pauline Naccache, Lionel Tallon-Baudry, Catherine Sitt, Jacobo D |
author_facet | Candia-Rivera, Diego Raimondo, Federico Pérez, Pauline Naccache, Lionel Tallon-Baudry, Catherine Sitt, Jacobo D |
author_sort | Candia-Rivera, Diego |
collection | PubMed |
description | Recent research suggests that brain-heart interactions are associated with perceptual and self-consciousness. In this line, the neural responses to visceral inputs have been hypothesized to play a leading role in shaping our subjective experience. This study aims to investigate whether the contextual processing of auditory irregularities modulates both direct neuronal responses to the auditory stimuli (ERPs) and the neural responses to heartbeats, as measured with heartbeat-evoked responses (HERs). HERs were computed in patients with disorders of consciousness, diagnosed with a minimally conscious state or unresponsive wakefulness syndrome. We tested whether HERs reflect conscious auditory perception, which can potentially provide additional information for the consciousness diagnosis. EEG recordings were taken during the local-global paradigm, which evaluates the capacity of a patient to detect the appearance of auditory irregularities at local (short-term) and global (long-term) levels. The results show that local and global effects produce distinct ERPs and HERs, which can help distinguish between the minimally conscious state and unresponsive wakefulness syndrome patients. Furthermore, we found that ERP and HER responses were not correlated suggesting that independent neuronal mechanisms are behind them. These findings suggest that HER modulations in response to auditory irregularities, especially local irregularities, may be used as a novel neural marker of consciousness and may aid in the bedside diagnosis of disorders of consciousness with a more cost-effective option than neuroimaging methods. |
format | Online Article Text |
id | pubmed-10651171 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | eLife Sciences Publications, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-106511712023-10-27 Conscious processing of global and local auditory irregularities causes differentiated heartbeat-evoked responses Candia-Rivera, Diego Raimondo, Federico Pérez, Pauline Naccache, Lionel Tallon-Baudry, Catherine Sitt, Jacobo D eLife Neuroscience Recent research suggests that brain-heart interactions are associated with perceptual and self-consciousness. In this line, the neural responses to visceral inputs have been hypothesized to play a leading role in shaping our subjective experience. This study aims to investigate whether the contextual processing of auditory irregularities modulates both direct neuronal responses to the auditory stimuli (ERPs) and the neural responses to heartbeats, as measured with heartbeat-evoked responses (HERs). HERs were computed in patients with disorders of consciousness, diagnosed with a minimally conscious state or unresponsive wakefulness syndrome. We tested whether HERs reflect conscious auditory perception, which can potentially provide additional information for the consciousness diagnosis. EEG recordings were taken during the local-global paradigm, which evaluates the capacity of a patient to detect the appearance of auditory irregularities at local (short-term) and global (long-term) levels. The results show that local and global effects produce distinct ERPs and HERs, which can help distinguish between the minimally conscious state and unresponsive wakefulness syndrome patients. Furthermore, we found that ERP and HER responses were not correlated suggesting that independent neuronal mechanisms are behind them. These findings suggest that HER modulations in response to auditory irregularities, especially local irregularities, may be used as a novel neural marker of consciousness and may aid in the bedside diagnosis of disorders of consciousness with a more cost-effective option than neuroimaging methods. eLife Sciences Publications, Ltd 2023-10-27 /pmc/articles/PMC10651171/ /pubmed/37888955 http://dx.doi.org/10.7554/eLife.75352 Text en © 2023, Candia-Rivera et al https://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Neuroscience Candia-Rivera, Diego Raimondo, Federico Pérez, Pauline Naccache, Lionel Tallon-Baudry, Catherine Sitt, Jacobo D Conscious processing of global and local auditory irregularities causes differentiated heartbeat-evoked responses |
title | Conscious processing of global and local auditory irregularities causes differentiated heartbeat-evoked responses |
title_full | Conscious processing of global and local auditory irregularities causes differentiated heartbeat-evoked responses |
title_fullStr | Conscious processing of global and local auditory irregularities causes differentiated heartbeat-evoked responses |
title_full_unstemmed | Conscious processing of global and local auditory irregularities causes differentiated heartbeat-evoked responses |
title_short | Conscious processing of global and local auditory irregularities causes differentiated heartbeat-evoked responses |
title_sort | conscious processing of global and local auditory irregularities causes differentiated heartbeat-evoked responses |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10651171/ https://www.ncbi.nlm.nih.gov/pubmed/37888955 http://dx.doi.org/10.7554/eLife.75352 |
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