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Growth and Nutritional Biomarkers in Brazilian Infants with Cow’s Milk Allergy at Diagnosis and 18-Month Follow-Up: A Prospective Cohort Study
PURPOSE: This study aimed to describe the growth, body protein status, and micronutrient biomarkers of Brazilian infants with cow’s milk allergy (CMPA) at baseline and at 18 months of follow-up in comparison with their healthy peers. METHODS: Thirty infants with CMPA younger than six months of age w...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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The Korean Society of Pediatric Gastroenterology, Hepatology and Nutrition
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10651362/ https://www.ncbi.nlm.nih.gov/pubmed/38025488 http://dx.doi.org/10.5223/pghn.2023.26.6.355 |
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author | Jardim-Botelho, Anne Martins, Tatiane Graça Motta-Franco, Jackeline Meyer, Rosan Fontes Vieira, Sarah Cristina Protásio, Bruna Franca Santos Silva, Milena Letícia Pontes, Rebecca Silveira de Oliveira, Marcela Barros Barbosa de Carvalho Barreto, Ikaro Daniel Gurgel, Ricardo Queiroz |
author_facet | Jardim-Botelho, Anne Martins, Tatiane Graça Motta-Franco, Jackeline Meyer, Rosan Fontes Vieira, Sarah Cristina Protásio, Bruna Franca Santos Silva, Milena Letícia Pontes, Rebecca Silveira de Oliveira, Marcela Barros Barbosa de Carvalho Barreto, Ikaro Daniel Gurgel, Ricardo Queiroz |
author_sort | Jardim-Botelho, Anne |
collection | PubMed |
description | PURPOSE: This study aimed to describe the growth, body protein status, and micronutrient biomarkers of Brazilian infants with cow’s milk allergy (CMPA) at baseline and at 18 months of follow-up in comparison with their healthy peers. METHODS: Thirty infants with CMPA younger than six months of age were included in this longitudinal study, and their nutritional status was compared with that of 24 non-allergic age-matched children. Anthropometric measurements were used to assess growth, and blood and urine samples were analyzed for protein and micronutrient status. Mixed linear models adjusted for birth weight, socioeconomic status, infant feeding at baseline, weight-for-age, C-reactive protein, serum albumin, micronutrient dietary supplementation, and salt consumption were employed to evaluate the evolution of nutritional parameters throughout the follow-up period. RESULTS: Overall, the mean age of the children at enrolment was 2.9 (standard deviation 1.7) months, and 29 children (53.7%) were male. Infants with CMPA showed a higher prevalence of functional iron depletion (transferrin saturation <20) (p=0.027), lower serum ferritin (p=0.009), and lower urinary iodine (p=0.034) levels than non-allergic children at baseline. Patients with CMPA showed a higher increment in weight-for-age and length-for-age over time than those in the control group (p<0.01). Mixed linear analyses showed a significantly lower increase in serum vitamin B12 (s-B12) (p=0.001) and urinary iodine (p<0.001) concentrations over time compared to the control group. CONCLUSION: Infants with CMPA on a cow’s milk elimination diet had a higher weight and length at 18 months of follow-up but showed signs of inadequate iron, iodine, and B-12 vitamin status. |
format | Online Article Text |
id | pubmed-10651362 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | The Korean Society of Pediatric Gastroenterology, Hepatology and Nutrition |
record_format | MEDLINE/PubMed |
spelling | pubmed-106513622023-11-01 Growth and Nutritional Biomarkers in Brazilian Infants with Cow’s Milk Allergy at Diagnosis and 18-Month Follow-Up: A Prospective Cohort Study Jardim-Botelho, Anne Martins, Tatiane Graça Motta-Franco, Jackeline Meyer, Rosan Fontes Vieira, Sarah Cristina Protásio, Bruna Franca Santos Silva, Milena Letícia Pontes, Rebecca Silveira de Oliveira, Marcela Barros Barbosa de Carvalho Barreto, Ikaro Daniel Gurgel, Ricardo Queiroz Pediatr Gastroenterol Hepatol Nutr Original Article PURPOSE: This study aimed to describe the growth, body protein status, and micronutrient biomarkers of Brazilian infants with cow’s milk allergy (CMPA) at baseline and at 18 months of follow-up in comparison with their healthy peers. METHODS: Thirty infants with CMPA younger than six months of age were included in this longitudinal study, and their nutritional status was compared with that of 24 non-allergic age-matched children. Anthropometric measurements were used to assess growth, and blood and urine samples were analyzed for protein and micronutrient status. Mixed linear models adjusted for birth weight, socioeconomic status, infant feeding at baseline, weight-for-age, C-reactive protein, serum albumin, micronutrient dietary supplementation, and salt consumption were employed to evaluate the evolution of nutritional parameters throughout the follow-up period. RESULTS: Overall, the mean age of the children at enrolment was 2.9 (standard deviation 1.7) months, and 29 children (53.7%) were male. Infants with CMPA showed a higher prevalence of functional iron depletion (transferrin saturation <20) (p=0.027), lower serum ferritin (p=0.009), and lower urinary iodine (p=0.034) levels than non-allergic children at baseline. Patients with CMPA showed a higher increment in weight-for-age and length-for-age over time than those in the control group (p<0.01). Mixed linear analyses showed a significantly lower increase in serum vitamin B12 (s-B12) (p=0.001) and urinary iodine (p<0.001) concentrations over time compared to the control group. CONCLUSION: Infants with CMPA on a cow’s milk elimination diet had a higher weight and length at 18 months of follow-up but showed signs of inadequate iron, iodine, and B-12 vitamin status. The Korean Society of Pediatric Gastroenterology, Hepatology and Nutrition 2023-11 2023-10-30 /pmc/articles/PMC10651362/ /pubmed/38025488 http://dx.doi.org/10.5223/pghn.2023.26.6.355 Text en Copyright © 2023 by The Korean Society of Pediatric Gastroenterology, Hepatology and Nutrition https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Jardim-Botelho, Anne Martins, Tatiane Graça Motta-Franco, Jackeline Meyer, Rosan Fontes Vieira, Sarah Cristina Protásio, Bruna Franca Santos Silva, Milena Letícia Pontes, Rebecca Silveira de Oliveira, Marcela Barros Barbosa de Carvalho Barreto, Ikaro Daniel Gurgel, Ricardo Queiroz Growth and Nutritional Biomarkers in Brazilian Infants with Cow’s Milk Allergy at Diagnosis and 18-Month Follow-Up: A Prospective Cohort Study |
title | Growth and Nutritional Biomarkers in Brazilian Infants with Cow’s Milk Allergy at Diagnosis and 18-Month Follow-Up: A Prospective Cohort Study |
title_full | Growth and Nutritional Biomarkers in Brazilian Infants with Cow’s Milk Allergy at Diagnosis and 18-Month Follow-Up: A Prospective Cohort Study |
title_fullStr | Growth and Nutritional Biomarkers in Brazilian Infants with Cow’s Milk Allergy at Diagnosis and 18-Month Follow-Up: A Prospective Cohort Study |
title_full_unstemmed | Growth and Nutritional Biomarkers in Brazilian Infants with Cow’s Milk Allergy at Diagnosis and 18-Month Follow-Up: A Prospective Cohort Study |
title_short | Growth and Nutritional Biomarkers in Brazilian Infants with Cow’s Milk Allergy at Diagnosis and 18-Month Follow-Up: A Prospective Cohort Study |
title_sort | growth and nutritional biomarkers in brazilian infants with cow’s milk allergy at diagnosis and 18-month follow-up: a prospective cohort study |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10651362/ https://www.ncbi.nlm.nih.gov/pubmed/38025488 http://dx.doi.org/10.5223/pghn.2023.26.6.355 |
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