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FOXD1 expression-based prognostic model for uveal melanoma
FOXD1, a new member of the FOX transcription factor family, serves as a mediator and biomarker for cell reprogramming. But its contribution to prognosis of uveal melanoma (UVM) is unclear. This study demonstrated that FOXD1 might promote tumor growth and invasion, because FOXD1 expression was negati...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10651470/ https://www.ncbi.nlm.nih.gov/pubmed/38027647 http://dx.doi.org/10.1016/j.heliyon.2023.e21333 |
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author | Luo, Yang Ni, Renhao Jin, Xiaojun Feng, Peipei Dai, Chenyi Jiang, Lingjing Chen, Pingping Yang, Lu Zhu, Yabin |
author_facet | Luo, Yang Ni, Renhao Jin, Xiaojun Feng, Peipei Dai, Chenyi Jiang, Lingjing Chen, Pingping Yang, Lu Zhu, Yabin |
author_sort | Luo, Yang |
collection | PubMed |
description | FOXD1, a new member of the FOX transcription factor family, serves as a mediator and biomarker for cell reprogramming. But its contribution to prognosis of uveal melanoma (UVM) is unclear. This study demonstrated that FOXD1 might promote tumor growth and invasion, because FOXD1 expression was negatively correlated with overall survival, progression-free survival, and disease-specific survival in UVM patients. This conjecture was verified in cell culture with human uveal melanoma cell line (MUM2B) as model cells. Additionally, the biological mechanisms of FOXD1 based on FOXD1-related genomic spectrum, molecular pathways, tumor microenvironment, and drug treatment sensitivity were examined using The Cancer Genome Atlas (TCGA) database, aiming to reasonably explain why FOXD1 leads to poor prognosis of UVM. On these bases, a novel tumor prognostic model was established using the FOXD1-related immunomodulators TMEM173, TNFRSF4, TNFSF13, and ULBP1, which will enable the stratification of disease seriousness and clinical treatment for patients. |
format | Online Article Text |
id | pubmed-10651470 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-106514702023-10-23 FOXD1 expression-based prognostic model for uveal melanoma Luo, Yang Ni, Renhao Jin, Xiaojun Feng, Peipei Dai, Chenyi Jiang, Lingjing Chen, Pingping Yang, Lu Zhu, Yabin Heliyon Research Article FOXD1, a new member of the FOX transcription factor family, serves as a mediator and biomarker for cell reprogramming. But its contribution to prognosis of uveal melanoma (UVM) is unclear. This study demonstrated that FOXD1 might promote tumor growth and invasion, because FOXD1 expression was negatively correlated with overall survival, progression-free survival, and disease-specific survival in UVM patients. This conjecture was verified in cell culture with human uveal melanoma cell line (MUM2B) as model cells. Additionally, the biological mechanisms of FOXD1 based on FOXD1-related genomic spectrum, molecular pathways, tumor microenvironment, and drug treatment sensitivity were examined using The Cancer Genome Atlas (TCGA) database, aiming to reasonably explain why FOXD1 leads to poor prognosis of UVM. On these bases, a novel tumor prognostic model was established using the FOXD1-related immunomodulators TMEM173, TNFRSF4, TNFSF13, and ULBP1, which will enable the stratification of disease seriousness and clinical treatment for patients. Elsevier 2023-10-23 /pmc/articles/PMC10651470/ /pubmed/38027647 http://dx.doi.org/10.1016/j.heliyon.2023.e21333 Text en © 2023 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Research Article Luo, Yang Ni, Renhao Jin, Xiaojun Feng, Peipei Dai, Chenyi Jiang, Lingjing Chen, Pingping Yang, Lu Zhu, Yabin FOXD1 expression-based prognostic model for uveal melanoma |
title | FOXD1 expression-based prognostic model for uveal melanoma |
title_full | FOXD1 expression-based prognostic model for uveal melanoma |
title_fullStr | FOXD1 expression-based prognostic model for uveal melanoma |
title_full_unstemmed | FOXD1 expression-based prognostic model for uveal melanoma |
title_short | FOXD1 expression-based prognostic model for uveal melanoma |
title_sort | foxd1 expression-based prognostic model for uveal melanoma |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10651470/ https://www.ncbi.nlm.nih.gov/pubmed/38027647 http://dx.doi.org/10.1016/j.heliyon.2023.e21333 |
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