Allometrically scaling tissue forces drive pathological foreign-body responses to implants via Rac2-activated myeloid cells

Small animals do not replicate the severity of the human foreign-body response (FBR) to implants. Here we show that the FBR can be driven by forces generated at the implant surface that, owing to allometric scaling, increase exponentially with body size. We found that the human FBR is mediated by im...

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Detalles Bibliográficos
Autores principales: Padmanabhan, Jagannath, Chen, Kellen, Sivaraj, Dharshan, Henn, Dominic, Kuehlmann, Britta A., Kussie, Hudson C., Zhao, Eric T., Kahn, Anum, Bonham, Clark A., Dohi, Teruyuki, Beck, Thomas C., Trotsyuk, Artem A., Stern-Buchbinder, Zachary A., Than, Peter A., Hosseini, Hadi S., Barrera, Janos A., Magbual, Noah J., Leeolou, Melissa C., Fischer, Katharina S., Tigchelaar, Seth S., Lin, John Q., Perrault, David P., Borrelli, Mimi R., Kwon, Sun Hyung, Maan, Zeshaan N., Dunn, James C. Y., Nazerali, Rahim, Januszyk, Michael, Prantl, Lukas, Gurtner, Geoffrey C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10651488/
https://www.ncbi.nlm.nih.gov/pubmed/37749310
http://dx.doi.org/10.1038/s41551-023-01091-5

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