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Ketogenic diets initiated in late mid-life improved measures of spatial memory in male mice
Studies have shown ketogenic diets (KD) started from early middle-age improved health span and longevity in mice. KDs started later in life or administered intermittently may be more feasible and promote compliance. Therefore, this study sought to test if continuous or intermittent KDs started in la...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer International Publishing
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10651563/ https://www.ncbi.nlm.nih.gov/pubmed/36933143 http://dx.doi.org/10.1007/s11357-023-00769-7 |
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author | Zhou, Zeyu Kim, Kyoungmi Ramsey, Jon J. Rutkowsky, Jennifer M. |
author_facet | Zhou, Zeyu Kim, Kyoungmi Ramsey, Jon J. Rutkowsky, Jennifer M. |
author_sort | Zhou, Zeyu |
collection | PubMed |
description | Studies have shown ketogenic diets (KD) started from early middle-age improved health span and longevity in mice. KDs started later in life or administered intermittently may be more feasible and promote compliance. Therefore, this study sought to test if continuous or intermittent KDs started in late-middle-aged mice would improve cognition and motor function at advanced age. Eighteen-month-old male C57BL/6JN mice were assigned to an isocaloric control (CD), KD, or intermittent ketogenic (IKD, 3-day KD/week) diet. A panel of behavior tests were performed to assess cognitive and motor functions with aging. Y-maze alternation rate was higher for both IKD and KD mice at 23 months of age and for KD mice at 26 months indicating an improved spatial working memory. Twenty-six-month-old KD mice also showed better spatial learning memory in Barnes maze when compared to the CD. Improved grid wire hang performance was observed in aged IKD and KD versus CD mice indicating better muscle endurance under isometric contraction. A reduced level of circulating proinflammatory cytokines in aged KD (IL-6 and TNF-α) and IKD (IL-6) mice may contribute to the phenotypic improvements observed with these interventions. This study demonstrates that when initiated at late-middle age, the KD improved measures of spatial memory and grid wire hang performance in aged male mice, with IKD showing results intermediate to the CD and KD groups. |
format | Online Article Text |
id | pubmed-10651563 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Springer International Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-106515632023-03-18 Ketogenic diets initiated in late mid-life improved measures of spatial memory in male mice Zhou, Zeyu Kim, Kyoungmi Ramsey, Jon J. Rutkowsky, Jennifer M. GeroScience Original Article Studies have shown ketogenic diets (KD) started from early middle-age improved health span and longevity in mice. KDs started later in life or administered intermittently may be more feasible and promote compliance. Therefore, this study sought to test if continuous or intermittent KDs started in late-middle-aged mice would improve cognition and motor function at advanced age. Eighteen-month-old male C57BL/6JN mice were assigned to an isocaloric control (CD), KD, or intermittent ketogenic (IKD, 3-day KD/week) diet. A panel of behavior tests were performed to assess cognitive and motor functions with aging. Y-maze alternation rate was higher for both IKD and KD mice at 23 months of age and for KD mice at 26 months indicating an improved spatial working memory. Twenty-six-month-old KD mice also showed better spatial learning memory in Barnes maze when compared to the CD. Improved grid wire hang performance was observed in aged IKD and KD versus CD mice indicating better muscle endurance under isometric contraction. A reduced level of circulating proinflammatory cytokines in aged KD (IL-6 and TNF-α) and IKD (IL-6) mice may contribute to the phenotypic improvements observed with these interventions. This study demonstrates that when initiated at late-middle age, the KD improved measures of spatial memory and grid wire hang performance in aged male mice, with IKD showing results intermediate to the CD and KD groups. Springer International Publishing 2023-03-18 /pmc/articles/PMC10651563/ /pubmed/36933143 http://dx.doi.org/10.1007/s11357-023-00769-7 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Original Article Zhou, Zeyu Kim, Kyoungmi Ramsey, Jon J. Rutkowsky, Jennifer M. Ketogenic diets initiated in late mid-life improved measures of spatial memory in male mice |
title | Ketogenic diets initiated in late mid-life improved measures of spatial memory in male mice |
title_full | Ketogenic diets initiated in late mid-life improved measures of spatial memory in male mice |
title_fullStr | Ketogenic diets initiated in late mid-life improved measures of spatial memory in male mice |
title_full_unstemmed | Ketogenic diets initiated in late mid-life improved measures of spatial memory in male mice |
title_short | Ketogenic diets initiated in late mid-life improved measures of spatial memory in male mice |
title_sort | ketogenic diets initiated in late mid-life improved measures of spatial memory in male mice |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10651563/ https://www.ncbi.nlm.nih.gov/pubmed/36933143 http://dx.doi.org/10.1007/s11357-023-00769-7 |
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