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Mechanisms associated with post-stroke depression and pharmacologic therapy
Stroke is one of the most common cerebrovascular diseases, which is the cause of long-term mental illness and physical disability, Post-stroke depression (PSD) is the most common neuropsychiatric complication after stroke, and its mechanisms are characterized by complexity, plurality, and diversity,...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10651767/ https://www.ncbi.nlm.nih.gov/pubmed/38020612 http://dx.doi.org/10.3389/fneur.2023.1274709 |
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author | Zhan, Qingyang Kong, Fanyi |
author_facet | Zhan, Qingyang Kong, Fanyi |
author_sort | Zhan, Qingyang |
collection | PubMed |
description | Stroke is one of the most common cerebrovascular diseases, which is the cause of long-term mental illness and physical disability, Post-stroke depression (PSD) is the most common neuropsychiatric complication after stroke, and its mechanisms are characterized by complexity, plurality, and diversity, which seriously affects the quality of survival and prognosis of patients. Studies have focused on and recognized neurotransmitter-based mechanisms and selective serotonin-reuptake inhibitors (SSRIs) can be used to treat PSD. Neuroinflammation, neuroendocrinology, neurotrophic factors, and the site of the stroke lesion may affect neurotransmitters. Thus the mechanisms of PSD have been increasingly studied. Pharmacological treatment mainly includes SSRIs, noradrenergic and specific serotonergic antidepressant (NaSSA), anti-inflammatory drugs, vitamin D, ect, which have been confirmed to have better efficacy by clinical studies. Currently, there is an increasing number of studies related to the mechanisms of PSD. However, the mechanisms and pharmacologic treatment of PSD is still unclear. In the future, in-depth research on the mechanisms and treatment of PSD is needed to provide a reference for the prevention and treatment of clinical PSD. |
format | Online Article Text |
id | pubmed-10651767 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-106517672023-11-02 Mechanisms associated with post-stroke depression and pharmacologic therapy Zhan, Qingyang Kong, Fanyi Front Neurol Neurology Stroke is one of the most common cerebrovascular diseases, which is the cause of long-term mental illness and physical disability, Post-stroke depression (PSD) is the most common neuropsychiatric complication after stroke, and its mechanisms are characterized by complexity, plurality, and diversity, which seriously affects the quality of survival and prognosis of patients. Studies have focused on and recognized neurotransmitter-based mechanisms and selective serotonin-reuptake inhibitors (SSRIs) can be used to treat PSD. Neuroinflammation, neuroendocrinology, neurotrophic factors, and the site of the stroke lesion may affect neurotransmitters. Thus the mechanisms of PSD have been increasingly studied. Pharmacological treatment mainly includes SSRIs, noradrenergic and specific serotonergic antidepressant (NaSSA), anti-inflammatory drugs, vitamin D, ect, which have been confirmed to have better efficacy by clinical studies. Currently, there is an increasing number of studies related to the mechanisms of PSD. However, the mechanisms and pharmacologic treatment of PSD is still unclear. In the future, in-depth research on the mechanisms and treatment of PSD is needed to provide a reference for the prevention and treatment of clinical PSD. Frontiers Media S.A. 2023-11-02 /pmc/articles/PMC10651767/ /pubmed/38020612 http://dx.doi.org/10.3389/fneur.2023.1274709 Text en Copyright © 2023 Zhan and Kong. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neurology Zhan, Qingyang Kong, Fanyi Mechanisms associated with post-stroke depression and pharmacologic therapy |
title | Mechanisms associated with post-stroke depression and pharmacologic therapy |
title_full | Mechanisms associated with post-stroke depression and pharmacologic therapy |
title_fullStr | Mechanisms associated with post-stroke depression and pharmacologic therapy |
title_full_unstemmed | Mechanisms associated with post-stroke depression and pharmacologic therapy |
title_short | Mechanisms associated with post-stroke depression and pharmacologic therapy |
title_sort | mechanisms associated with post-stroke depression and pharmacologic therapy |
topic | Neurology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10651767/ https://www.ncbi.nlm.nih.gov/pubmed/38020612 http://dx.doi.org/10.3389/fneur.2023.1274709 |
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