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Aberrant function of pathogenic STAT3 mutant proteins is linked to altered stability of monomers and homodimers

STAT3 mutations, predominantly in the DNA-binding domain (DBD) and Src-homology 2 domain (SH2D), cause rare cases of immunodeficiency, malignancy, and autoimmunity. The exact mechanisms by which these mutations abrogate or enhance STAT3 function are not completely understood. Here, we examined how l...

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Detalles Bibliográficos
Autores principales:	Kasembeli, Moses M., Kaparos, Efiyenia, Bharadwaj, Uddalak, Allaw, Ahmad, Khouri, Alain, Acot, Bianca, Tweardy, David J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The American Society of Hematology 2023
Materias:	Immunobiology and Immunotherapy
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10651785/ https://www.ncbi.nlm.nih.gov/pubmed/36240433 http://dx.doi.org/10.1182/blood.2021015330

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