A novel RIPK1 inhibitor reduces GVHD in mice via a nonimmunosuppressive mechanism that restores intestinal homeostasis

Intestinal epithelial cells (IECs) are implicated in the propagation of T-cell–mediated inflammatory diseases, including graft-versus-host disease (GVHD), but the underlying mechanism remains poorly defined. Here, we report that IECs require receptor-interacting protein kinase-3 (RIPK3) to drive bot...

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Detalles Bibliográficos
Autores principales: Yu, Xiaoliang, Ma, Haikuo, Li, Bohan, Ji, Yuting, Du, Yayun, Liu, Siying, Li, Zhanhui, Hao, Yongjin, Tian, Sheng, Zhao, Cong, Du, Qian, Jin, Zhongqin, Zhu, Xueming, Tian, Yuanyuan, Chen, Xin, Sun, Xue, Yang, Chengkui, Zhu, Fang, Ju, Jie, Zheng, Yunjing, Zhang, Wei, Wang, Jingrui, Yang, Tao, Wang, Xinhui, Li, Jingjing, Xu, Xiangping, Du, Shujing, Lu, Haohao, Ma, Feng, Zhang, Haibing, Zhang, Yi, Zhang, Xiaohu, Hu, Shaoyan, He, Sudan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society of Hematology 2023
Materias:
Transplantation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10651787/
https://www.ncbi.nlm.nih.gov/pubmed/36356302
http://dx.doi.org/10.1182/blood.2022017262

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