mTOR inhibition suppresses salinomycin-induced ferroptosis in breast cancer stem cells by ironing out mitochondrial dysfunctions

Ferroptosis constitutes a promising therapeutic strategy against cancer by efficiently targeting the highly tumorigenic and treatment-resistant cancer stem cells (CSCs). We previously showed that the lysosomal iron-targeting drug Salinomycin (Sal) was able to eliminate CSCs by triggering ferroptosis...

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Detalles Bibliográficos
Autores principales: Cosialls, Emma, Pacreau, Emeline, Duruel, Clémence, Ceccacci, Sara, Elhage, Rima, Desterke, Christophe, Roger, Kevin, Guerrera, Chiara, Ducloux, Romane, Souquere, Sylvie, Pierron, Gérard, Nemazanyy, Ivan, Kelly, Mairead, Dalmas, Elise, Chang, Yunhua, Goffin, Vincent, Mehrpour, Maryam, Hamaï, Ahmed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10651934/
https://www.ncbi.nlm.nih.gov/pubmed/37968262
http://dx.doi.org/10.1038/s41419-023-06262-5

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