Cargando…

Bispecific soluble cytokine receptor-nanobody fusions inhibit Interleukin (IL-)6 trans-signaling and IL-12/23 or tumor necrosis factor (TNF) signaling

At least 0.5% of people in the Western world develop inflammatory bowel disease (IBD). While antibodies that block tumor necrosis factor (TNF) α and Interleukin (IL-)23 have been approved for the treatment of IBD, IL-6 antibodies failed in the phase II clinical trial due to non-tolerable side effect...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gesiorowski, Annika, Ettich, Julia, Werner, Julia, Wittich, Christoph, Pieper, Stephan, Padrini, Giacomo, Behnke, Kristina, Floss, Doreen M., Lang, Philipp A., Moll, Jens M., Scheller, Jürgen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10652096/ https://www.ncbi.nlm.nih.gov/pubmed/37838173 http://dx.doi.org/10.1016/j.jbc.2023.105343

Ejemplares similares

Exclusive inhibition of IL-6 trans-signaling by soluble gp130(FlyR)Fc
por: Berg, Anna F., et al.
Publicado: (2021)

Cytokimera GIL-11 rescued IL-6R deficient mice from partial hepatectomy-induced death by signaling via non-natural gp130:LIFR:IL-11R complexes
por: Rafii, Puyan, et al.
Publicado: (2023)

Respiratory syncytial virus–approved mAb Palivizumab as ligand for anti-idiotype nanobody-based synthetic cytokine receptors
por: Ettich, Julia, et al.
Publicado: (2023)

A Hybrid Soluble gp130/Spike-Nanobody Fusion Protein Simultaneously Blocks Interleukin-6 trans-Signaling and Cellular Infection with SARS-CoV-2
por: Ettich, Julia, et al.
Publicado: (2022)

IL-12 and IL-23—Close Relatives with Structural Homologies but Distinct Immunological Functions
por: Floss, Doreen M., et al.
Publicado: (2020)

Tryptophan (W) at position 37 of murine IL-12/IL-23 p40 is mandatory for binding to IL-12Rβ1 and subsequent signal transduction
por: Georgy, Jacqueline, et al.
Publicado: (2021)

Targeting IL-6 trans-signalling: past, present and future prospects
por: Rose-John, Stefan, et al.
Publicado: (2023)

IL-6/IL-12 Cytokine Receptor Shuffling of Extra- and Intracellular Domains Reveals Canonical STAT Activation via Synthetic IL-35 and IL-39 Signaling
por: Floss, D. M., et al.
Publicado: (2017)

IL-23R Signaling Plays No Role in Myocardial Infarction
por: Engelowski, Erika, et al.
Publicado: (2018)

Preclinical development of a long-acting trivalent bispecific nanobody targeting IL-5 for the treatment of eosinophilic asthma
por: Ma, Linlin, et al.
Publicado: (2022)

Classical Signaling and Trans-Signaling Pathways Stimulated by Megalobrama amblycephala IL-6 and IL-6R
por: Wang, Jixiu, et al.
Publicado: (2022)

Targeting IL-6 Trans-Signaling: Amplifying the Benefits of IL-6 Inhibition in Myocardial Infarction
por: Aukrust, Pål, et al.
Publicado: (2021)

IL-6 Trans-Signaling via the Soluble IL-6 Receptor: Importance for the Pro-Inflammatory Activities of IL-6
por: Rose-John, Stefan
Publicado: (2012)

ADAM17 Activity and IL-6 Trans-Signaling in Inflammation and Cancer
por: Schumacher, Neele, et al.
Publicado: (2019)

IL6 trans-signaling associates with ischemic stroke but not with atrial fibrillation
por: Ziegler, Louise, et al.
Publicado: (2021)

IL-6 trans-signaling in a humanized mouse model of scleroderma
por: Odell, Ian D., et al.
Publicado: (2023)

Targeting multiple myeloma with nanobody-based heavy chain antibodies, bispecific killer cell engagers, chimeric antigen receptors, and nanobody-displaying AAV vectors
por: Hambach, Julia, et al.
Publicado: (2022)

Cathepsin S provokes interleukin-6 (IL-6) trans-signaling through cleavage of the IL-6 receptor in vitro
por: Flynn, Charlotte M., et al.
Publicado: (2020)

Liver injury in COVID-19 and IL-6 trans-signaling-induced endotheliopathy
por: McConnell, Matthew J., et al.
Publicado: (2021)

Correction: IL6 trans-signaling associates with ischemic stroke but not with atrial fibrillation
por: Ziegler, Louise, et al.
Publicado: (2022)

Adipocyte-Secreted IL-6 Sensitizes Macrophages to IL-4 Signaling
por: Luan, Danny, et al.
Publicado: (2023)

IL-6 in the infarcted heart is preferentially formed by fibroblasts and modulated by purinergic signaling
por: Alter, Christina, et al.
Publicado: (2023)

Experiment-based Computational Model Predicts that IL-6 Trans-Signaling Plays a Dominant Role in IL-6 mediated signaling in Endothelial Cells
por: Song, Min, et al.
Publicado: (2023)

Discovery and characterization of COVA322, a clinical-stage bispecific TNF/IL-17A inhibitor for the treatment of inflammatory diseases
por: Silacci, Michela, et al.
Publicado: (2015)

Blockade of IL-36 Receptor Signaling Does Not Prevent from TNF-Induced Arthritis
por: Derer, Anja, et al.
Publicado: (2014)

ADAM17 is required for EGF-R–induced intestinal tumors via IL-6 trans-signaling
por: Schmidt, Stefanie, et al.
Publicado: (2018)

TNF-α, TNF-β, IL-6, and IL-10 Polymorphisms in Patients with Lung Cancer
por: Seifart, Carola, et al.
Publicado: (2005)

Circulating IL-6, IL-10, and TNF-alpha and IL-10/IL-6 and IL-10/TNF-alpha ratio profiles of polyparasitized individuals in rural and urban areas of gabon
por: M’Bondoukwé, Noé Patrick, et al.
Publicado: (2022)

Inflammatory cytokines TNFα, IL-1β, and IL-6 are induced in endotoxin- stimulated microglia through different signaling cascades
por: Ishijima, Takashi, et al.
Publicado: (2021)

Fully synthetic platform to rapidly generate tetravalent bispecific nanobody–based immunoglobulins
por: Misson Mindrebo, Laetitia, et al.
Publicado: (2023)

Pro- and anti-apoptotic fate decisions induced by di- and trimeric synthetic cytokine receptors
por: Mossner, Sofie, et al.
Publicado: (2021)

Response to IL-6 trans- and IL-6 classic signalling is determined by the ratio of the IL-6 receptor α to gp130 expression: fusing experimental insights and dynamic modelling
por: Reeh, Heike, et al.
Publicado: (2019)

Regulation of IL-9 expression by IL-25 signaling
por: Angkasekwinai, Pornpimon, et al.
Publicado: (2010)

Diabetes Induced Alterations in Murine Vitreous Proteome Are Mitigated by IL-6 Trans-Signaling Inhibition
por: Robinson, Rebekah, et al.
Publicado: (2020)

Macrophage-derived IL-6 trans-signalling as a novel target in the pathogenesis of bronchopulmonary dysplasia
por: Hirani, Dharmesh, et al.
Publicado: (2022)

Mathematical modeling and application of IL-1β/TNF signaling pathway in regulating chondrocyte apoptosis
por: Wang, Yishu, et al.
Publicado: (2023)

Preclinical development of a bispecific TNFα/IL-23 neutralising domain antibody as a novel oral treatment for inflammatory bowel disease
por: Roberts, Kevin J., et al.
Publicado: (2021)

Methamphetamine Increases LPS-Mediated Expression of IL-8, TNF-α and IL-1β in Human Macrophages through Common Signaling Pathways
por: Liu, Xun, et al.
Publicado: (2012)

Synthetic cytokine receptors transmit biological signals using artificial ligands
por: Engelowski, Erika, et al.
Publicado: (2018)

Effects of febuxostat on serum cytokines IL-1, IL-4, IL-6, IL-8, TNF-α and COX-2
por: Hao, Guohua, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_b0tnpgprp3dntj7bdkgf8m9o5c