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A Rare Case of Placental Abruption and Postpartum Compression Fractures in Pregnancy With Cushing Syndrome
Cushing syndrome (CS) is a disorder rarely found during pregnancy. Patients with CS usually receive treatment before pregnancy. In addition, hypercortisolism suppresses gonadotropins, leading to amenorrhea or irregular menstruation. Therefore, few reports have described cases of pregnancy with untre...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10652248/ https://www.ncbi.nlm.nih.gov/pubmed/38021078 http://dx.doi.org/10.1210/jcemcr/luad128 |
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author | Iioka, Masahito Hayakawa, Tomoaki Otsuki, Michio Shimomura, Iichiro |
author_facet | Iioka, Masahito Hayakawa, Tomoaki Otsuki, Michio Shimomura, Iichiro |
author_sort | Iioka, Masahito |
collection | PubMed |
description | Cushing syndrome (CS) is a disorder rarely found during pregnancy. Patients with CS usually receive treatment before pregnancy. In addition, hypercortisolism suppresses gonadotropins, leading to amenorrhea or irregular menstruation. Therefore, few reports have described cases of pregnancy with untreated CS. Here, we observed the changes in the cortisol level of a 38-year-old woman with adrenal CS before and throughout pregnancy and delivery. She also had primary aldosteronism, and we were able to follow her plasma aldosterone levels. Her symptoms of CS before pregnancy were submandibular acne and irregular menstruation, but after conception, “moon face” and fatigue appeared. Laboratory tests also revealed impaired glucose tolerance, hypokalemia, lymphocytopenia, and increased urinary free cortisol levels. After administration of metyrapone to ameliorate her general condition, laparoscopic adrenalectomy was performed in the nineteenth week of pregnancy. After the operation, the patient's symptoms improved, and the cortisol level was maintained with hydrocortisone supplementation. The patient's plasma aldosterone level and blood pressure did not deteriorate throughout the course. However, the delivery was complicated by placental abruption. One month after delivery, the mother presented with compression fractures. We review the literature and discuss the treatment and complications of pregnancy with CS. |
format | Online Article Text |
id | pubmed-10652248 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-106522482023-11-16 A Rare Case of Placental Abruption and Postpartum Compression Fractures in Pregnancy With Cushing Syndrome Iioka, Masahito Hayakawa, Tomoaki Otsuki, Michio Shimomura, Iichiro JCEM Case Rep Case Report Cushing syndrome (CS) is a disorder rarely found during pregnancy. Patients with CS usually receive treatment before pregnancy. In addition, hypercortisolism suppresses gonadotropins, leading to amenorrhea or irregular menstruation. Therefore, few reports have described cases of pregnancy with untreated CS. Here, we observed the changes in the cortisol level of a 38-year-old woman with adrenal CS before and throughout pregnancy and delivery. She also had primary aldosteronism, and we were able to follow her plasma aldosterone levels. Her symptoms of CS before pregnancy were submandibular acne and irregular menstruation, but after conception, “moon face” and fatigue appeared. Laboratory tests also revealed impaired glucose tolerance, hypokalemia, lymphocytopenia, and increased urinary free cortisol levels. After administration of metyrapone to ameliorate her general condition, laparoscopic adrenalectomy was performed in the nineteenth week of pregnancy. After the operation, the patient's symptoms improved, and the cortisol level was maintained with hydrocortisone supplementation. The patient's plasma aldosterone level and blood pressure did not deteriorate throughout the course. However, the delivery was complicated by placental abruption. One month after delivery, the mother presented with compression fractures. We review the literature and discuss the treatment and complications of pregnancy with CS. Oxford University Press 2023-11-16 /pmc/articles/PMC10652248/ /pubmed/38021078 http://dx.doi.org/10.1210/jcemcr/luad128 Text en © The Author(s) 2023. Published by Oxford University Press on behalf of the Endocrine Society. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com |
spellingShingle | Case Report Iioka, Masahito Hayakawa, Tomoaki Otsuki, Michio Shimomura, Iichiro A Rare Case of Placental Abruption and Postpartum Compression Fractures in Pregnancy With Cushing Syndrome |
title | A Rare Case of Placental Abruption and Postpartum Compression Fractures in Pregnancy With Cushing Syndrome |
title_full | A Rare Case of Placental Abruption and Postpartum Compression Fractures in Pregnancy With Cushing Syndrome |
title_fullStr | A Rare Case of Placental Abruption and Postpartum Compression Fractures in Pregnancy With Cushing Syndrome |
title_full_unstemmed | A Rare Case of Placental Abruption and Postpartum Compression Fractures in Pregnancy With Cushing Syndrome |
title_short | A Rare Case of Placental Abruption and Postpartum Compression Fractures in Pregnancy With Cushing Syndrome |
title_sort | rare case of placental abruption and postpartum compression fractures in pregnancy with cushing syndrome |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10652248/ https://www.ncbi.nlm.nih.gov/pubmed/38021078 http://dx.doi.org/10.1210/jcemcr/luad128 |
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