Disuse‐induced muscle fibrosis, cellular senescence, and senescence‐associated secretory phenotype in older adults are alleviated during re‐ambulation with metformin pre‐treatment

Muscle inflammation and fibrosis underlie disuse‐related complications and may contribute to impaired muscle recovery in aging. Cellular senescence is an emerging link between inflammation, extracellular matrix (ECM) remodeling and poor muscle recovery after disuse. In rodents, metformin has been sh...

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Detalles Bibliográficos
Autores principales: Petrocelli, Jonathan J., McKenzie, Alec I., de Hart, Naomi M. M. P., Reidy, Paul T., Mahmassani, Ziad S., Keeble, Alexander R., Kaput, Katie L., Wahl, Matthew P., Rondina, Matthew T., Marcus, Robin L., Welt, Corrine K., Holland, William L., Funai, Katsuhiko, Fry, Christopher S., Drummond, Micah J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10652302/
https://www.ncbi.nlm.nih.gov/pubmed/37486024
http://dx.doi.org/10.1111/acel.13936

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