Senolytic treatment reduces oxidative protein stress in an aging male murine model of post‐traumatic osteoarthritis

Senolytic drugs are designed to selectively clear senescent cells (SnCs) that accumulate with injury or aging. In a mouse model of osteoarthritis (OA), senolysis yields a pro‐regenerative response, but the therapeutic benefit is reduced in aged mice. Increased oxidative stress is a hallmark of advan...

Descripción completa

Detalles Bibliográficos
Autores principales: Chin, Alexander F., Han, Jin, Clement, Cristina C., Choi, Younghwan, Zhang, Hong, Browne, Maria, Jeon, Ok Hee, Elisseeff, Jennifer H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10652304/
https://www.ncbi.nlm.nih.gov/pubmed/37749958
http://dx.doi.org/10.1111/acel.13979

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10652304/
https://www.ncbi.nlm.nih.gov/pubmed/37749958
http://dx.doi.org/10.1111/acel.13979

Ejemplares similares