PKCδ regulates the vascular biology in diabetic atherosclerosis

Diabetes mellitus, known for its complications, especially vascular complications, is becoming a globally serious social problem. Atherosclerosis has been recognized as a common vascular complication mechanism in diabetes. The diacylglycerol (DAG)–protein kinase C (PKC) pathway plays an important ro...

Descripción completa

Detalles Bibliográficos
Autores principales: Qin, Peiliang, He, Changhuai, Ye, Pin, Li, Qin, Cai, Chuanqi, Li, Yiqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10652453/
https://www.ncbi.nlm.nih.gov/pubmed/37974282
http://dx.doi.org/10.1186/s12964-023-01361-4
Descripción
Sumario:Diabetes mellitus, known for its complications, especially vascular complications, is becoming a globally serious social problem. Atherosclerosis has been recognized as a common vascular complication mechanism in diabetes. The diacylglycerol (DAG)–protein kinase C (PKC) pathway plays an important role in atherosclerosis. PKCs can be divided into three subgroups: conventional PKCs (cPKCs), novel PKCs (nPKCs), and atypical PKCs (aPKCs). The aim of this review is to provide a comprehensive overview of the role of the PKCδ pathway, an isoform of nPKC, in regulating the function of endothelial cells, vascular smooth muscle cells, and macrophages in diabetic atherosclerosis. In addition, potential therapeutic targets regarding the PKCδ pathway are summarized. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12964-023-01361-4.

Ejemplares similares