PKCδ regulates the vascular biology in diabetic atherosclerosis

Diabetes mellitus, known for its complications, especially vascular complications, is becoming a globally serious social problem. Atherosclerosis has been recognized as a common vascular complication mechanism in diabetes. The diacylglycerol (DAG)–protein kinase C (PKC) pathway plays an important ro...

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Autores principales: Qin, Peiliang, He, Changhuai, Ye, Pin, Li, Qin, Cai, Chuanqi, Li, Yiqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10652453/
https://www.ncbi.nlm.nih.gov/pubmed/37974282
http://dx.doi.org/10.1186/s12964-023-01361-4
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author Qin, Peiliang
He, Changhuai
Ye, Pin
Li, Qin
Cai, Chuanqi
Li, Yiqing
author_facet Qin, Peiliang
He, Changhuai
Ye, Pin
Li, Qin
Cai, Chuanqi
Li, Yiqing
author_sort Qin, Peiliang
collection PubMed
description Diabetes mellitus, known for its complications, especially vascular complications, is becoming a globally serious social problem. Atherosclerosis has been recognized as a common vascular complication mechanism in diabetes. The diacylglycerol (DAG)–protein kinase C (PKC) pathway plays an important role in atherosclerosis. PKCs can be divided into three subgroups: conventional PKCs (cPKCs), novel PKCs (nPKCs), and atypical PKCs (aPKCs). The aim of this review is to provide a comprehensive overview of the role of the PKCδ pathway, an isoform of nPKC, in regulating the function of endothelial cells, vascular smooth muscle cells, and macrophages in diabetic atherosclerosis. In addition, potential therapeutic targets regarding the PKCδ pathway are summarized. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12964-023-01361-4.
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spelling pubmed-106524532023-11-16 PKCδ regulates the vascular biology in diabetic atherosclerosis Qin, Peiliang He, Changhuai Ye, Pin Li, Qin Cai, Chuanqi Li, Yiqing Cell Commun Signal Review Diabetes mellitus, known for its complications, especially vascular complications, is becoming a globally serious social problem. Atherosclerosis has been recognized as a common vascular complication mechanism in diabetes. The diacylglycerol (DAG)–protein kinase C (PKC) pathway plays an important role in atherosclerosis. PKCs can be divided into three subgroups: conventional PKCs (cPKCs), novel PKCs (nPKCs), and atypical PKCs (aPKCs). The aim of this review is to provide a comprehensive overview of the role of the PKCδ pathway, an isoform of nPKC, in regulating the function of endothelial cells, vascular smooth muscle cells, and macrophages in diabetic atherosclerosis. In addition, potential therapeutic targets regarding the PKCδ pathway are summarized. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12964-023-01361-4. BioMed Central 2023-11-16 /pmc/articles/PMC10652453/ /pubmed/37974282 http://dx.doi.org/10.1186/s12964-023-01361-4 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Qin, Peiliang
He, Changhuai
Ye, Pin
Li, Qin
Cai, Chuanqi
Li, Yiqing
PKCδ regulates the vascular biology in diabetic atherosclerosis
title PKCδ regulates the vascular biology in diabetic atherosclerosis
title_full PKCδ regulates the vascular biology in diabetic atherosclerosis
title_fullStr PKCδ regulates the vascular biology in diabetic atherosclerosis
title_full_unstemmed PKCδ regulates the vascular biology in diabetic atherosclerosis
title_short PKCδ regulates the vascular biology in diabetic atherosclerosis
title_sort pkcδ regulates the vascular biology in diabetic atherosclerosis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10652453/
https://www.ncbi.nlm.nih.gov/pubmed/37974282
http://dx.doi.org/10.1186/s12964-023-01361-4
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