Epigenetic-focused CRISPR/Cas9 screen identifies (absent, small, or homeotic)2-like protein (ASH2L) as a regulator of glioblastoma cell survival

BACKGROUND: Glioblastoma is the most common and aggressive primary brain tumor with extremely poor prognosis, highlighting an urgent need for developing novel treatment options. Identifying epigenetic vulnerabilities of cancer cells can provide excellent therapeutic intervention points for various t...

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Detalles Bibliográficos
Autores principales: Ozyerli-Goknar, Ezgi, Kala, Ezgi Yagmur, Aksu, Ali Cenk, Bulut, Ipek, Cingöz, Ahmet, Nizamuddin, Sheikh, Biniossek, Martin, Seker-Polat, Fidan, Morova, Tunc, Aztekin, Can, Kung, Sonia H. Y., Syed, Hamzah, Tuncbag, Nurcan, Gönen, Mehmet, Philpott, Martin, Cribbs, Adam P., Acilan, Ceyda, Lack, Nathan A., Onder, Tamer T., Timmers, H. T. Marc, Bagci-Onder, Tugba
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10652464/
https://www.ncbi.nlm.nih.gov/pubmed/37974198
http://dx.doi.org/10.1186/s12964-023-01335-6

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