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Discovery of potent STAT3 inhibitors using structure-based virtual screening, molecular dynamic simulation, and biological evaluation

INTRODUCTION: Signal transducer and activator of transcription 3 (STAT3) is ubiquitously hyper-activated in numerous cancers, rendering it an appealing target for therapeutic intervention. METHODS AND RESULTS: In this study, using structure-based virtual screening complemented by molecular dynamics...

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Detalles Bibliográficos
Autores principales:	Liu, Weifeng, Chu, Zhijie, Yang, Cheng, Yang, Tianbao, Yang, Yanhui, Wu, Haigang, Sun, Junjun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Oncology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10652556/ https://www.ncbi.nlm.nih.gov/pubmed/38023173 http://dx.doi.org/10.3389/fonc.2023.1287797

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