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Analysis of the clinical efficacy of laparoscopic middle pancreatectomy in the treatment of benign or low-grade malignant tumors of the pancreas

OBJECTIVE: The aim of this study was to investigate the clinical efficacy of laparoscopic middle pancreatectomy in the treatment of benign and junctional tumors of the pancreas. METHODS: Retrospective analysis of basic data, tumor diameter, statistical analysis, and evaluation of efficacy-related in...

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Autores principales: Liao, Yan, Zhou, Wei, Dai, Manxiong, Zhou, Jie, Wang, Yi, He, Xiangyu, Liu, Yi, Cheng, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10652557/
https://www.ncbi.nlm.nih.gov/pubmed/38023120
http://dx.doi.org/10.3389/fonc.2023.1231647
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author Liao, Yan
Zhou, Wei
Dai, Manxiong
Zhou, Jie
Wang, Yi
He, Xiangyu
Liu, Yi
Cheng, Wei
author_facet Liao, Yan
Zhou, Wei
Dai, Manxiong
Zhou, Jie
Wang, Yi
He, Xiangyu
Liu, Yi
Cheng, Wei
author_sort Liao, Yan
collection PubMed
description OBJECTIVE: The aim of this study was to investigate the clinical efficacy of laparoscopic middle pancreatectomy in the treatment of benign and junctional tumors of the pancreas. METHODS: Retrospective analysis of basic data, tumor diameter, statistical analysis, and evaluation of efficacy-related indicators such as operative time, intraoperative bleeding, pathological findings, postoperative hospital stay, postoperative pancreatic fistula incidence, and pancreatic endocrine function was carried out on 17 patients diagnosed with benign or low-grade malignant tumors of the pancreas and laparoscopic middle pancreatic resection from January 2018 to January 2023 at the First Affiliated Hospital of Hunan Normal University. RESULTS: A total of 17 patients were screened. There were eight males and nine females; mean age was 42.8 ± 17.4 years (range: 15–69 years); BMI was 22.6 ± 2.5 kg/m2 (range: 18.4–27.5 kg/m2), and the tumor size was 3.4 ± 1.2 cm (range: 1.5–5.5 cm). Preoperative glycan antigen CA19-9 was negative and CA125 was negative. Surgical time was 393.2 ± 57.9 min; intraoperative bleeding was 211.7 ± 113.9 ml; tumor diameter size was 3.4 ± 1.2 cm; postoperative admission time was 19.4 ± 7.6 days; postoperative pancreatic fistula (POPF) grading was 17 cases, including nine cases of A-grade fistula, three cases of B-grade fistula, and none of C-grade fistula; postoperative pathology results were five cases of plasmacytoma, three cases of mucinous cystadenoma, four cases of SPN (solid pseudopapillary neoplasm), one case of Intraductal Papillary Mucinous Neoplasm (IPMN), three cases of pancreatic Neuroendocrine Neoplasm (pNEN), one case of inflammatory myofibroblastic osteoblastoma. All cases did not develop pancreatic origin diabetes or exacerbation of previous diabetes, and no cases presented symptoms of exocrine insufficiency such as dyspepsia and diarrhea. CONCLUSION: Laparoscopic middle pancreatectomy is safe and feasible in the treatment of benign or low-grade malignant tumors in the body of the pancreatic neck and is not accompanied by increased risk of intraoperative and postoperative complications and endocrine dysfunction of the pancreas.
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spelling pubmed-106525572023-01-01 Analysis of the clinical efficacy of laparoscopic middle pancreatectomy in the treatment of benign or low-grade malignant tumors of the pancreas Liao, Yan Zhou, Wei Dai, Manxiong Zhou, Jie Wang, Yi He, Xiangyu Liu, Yi Cheng, Wei Front Oncol Oncology OBJECTIVE: The aim of this study was to investigate the clinical efficacy of laparoscopic middle pancreatectomy in the treatment of benign and junctional tumors of the pancreas. METHODS: Retrospective analysis of basic data, tumor diameter, statistical analysis, and evaluation of efficacy-related indicators such as operative time, intraoperative bleeding, pathological findings, postoperative hospital stay, postoperative pancreatic fistula incidence, and pancreatic endocrine function was carried out on 17 patients diagnosed with benign or low-grade malignant tumors of the pancreas and laparoscopic middle pancreatic resection from January 2018 to January 2023 at the First Affiliated Hospital of Hunan Normal University. RESULTS: A total of 17 patients were screened. There were eight males and nine females; mean age was 42.8 ± 17.4 years (range: 15–69 years); BMI was 22.6 ± 2.5 kg/m2 (range: 18.4–27.5 kg/m2), and the tumor size was 3.4 ± 1.2 cm (range: 1.5–5.5 cm). Preoperative glycan antigen CA19-9 was negative and CA125 was negative. Surgical time was 393.2 ± 57.9 min; intraoperative bleeding was 211.7 ± 113.9 ml; tumor diameter size was 3.4 ± 1.2 cm; postoperative admission time was 19.4 ± 7.6 days; postoperative pancreatic fistula (POPF) grading was 17 cases, including nine cases of A-grade fistula, three cases of B-grade fistula, and none of C-grade fistula; postoperative pathology results were five cases of plasmacytoma, three cases of mucinous cystadenoma, four cases of SPN (solid pseudopapillary neoplasm), one case of Intraductal Papillary Mucinous Neoplasm (IPMN), three cases of pancreatic Neuroendocrine Neoplasm (pNEN), one case of inflammatory myofibroblastic osteoblastoma. All cases did not develop pancreatic origin diabetes or exacerbation of previous diabetes, and no cases presented symptoms of exocrine insufficiency such as dyspepsia and diarrhea. CONCLUSION: Laparoscopic middle pancreatectomy is safe and feasible in the treatment of benign or low-grade malignant tumors in the body of the pancreatic neck and is not accompanied by increased risk of intraoperative and postoperative complications and endocrine dysfunction of the pancreas. Frontiers Media S.A. 2023-11-02 /pmc/articles/PMC10652557/ /pubmed/38023120 http://dx.doi.org/10.3389/fonc.2023.1231647 Text en Copyright © 2023 Liao, Zhou, Dai, Zhou, Wang, He, Liu and Cheng https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Liao, Yan
Zhou, Wei
Dai, Manxiong
Zhou, Jie
Wang, Yi
He, Xiangyu
Liu, Yi
Cheng, Wei
Analysis of the clinical efficacy of laparoscopic middle pancreatectomy in the treatment of benign or low-grade malignant tumors of the pancreas
title Analysis of the clinical efficacy of laparoscopic middle pancreatectomy in the treatment of benign or low-grade malignant tumors of the pancreas
title_full Analysis of the clinical efficacy of laparoscopic middle pancreatectomy in the treatment of benign or low-grade malignant tumors of the pancreas
title_fullStr Analysis of the clinical efficacy of laparoscopic middle pancreatectomy in the treatment of benign or low-grade malignant tumors of the pancreas
title_full_unstemmed Analysis of the clinical efficacy of laparoscopic middle pancreatectomy in the treatment of benign or low-grade malignant tumors of the pancreas
title_short Analysis of the clinical efficacy of laparoscopic middle pancreatectomy in the treatment of benign or low-grade malignant tumors of the pancreas
title_sort analysis of the clinical efficacy of laparoscopic middle pancreatectomy in the treatment of benign or low-grade malignant tumors of the pancreas
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10652557/
https://www.ncbi.nlm.nih.gov/pubmed/38023120
http://dx.doi.org/10.3389/fonc.2023.1231647
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