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Chemical engineering of the peptidyl transferase center reveals an important role of the 2′-hydroxyl group of A2451

The main enzymatic reaction of the large ribosomal subunit is peptide bond formation. Ribosome crystallography showed that A2451 of 23S rRNA makes the closest approach to the attacking amino group of aminoacyl-tRNA. Mutations of A2451 had relatively small effects on transpeptidation and failed to un...

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Detalles Bibliográficos
Autores principales:	Erlacher, Matthias D., Lang, Kathrin, Shankaran, Nisha, Wotzel, Brigitte, Hüttenhofer, Alexander, Micura, Ronald, Mankin, Alexander S., Polacek, Norbert
Formato:	Texto
Lenguaje:	English
Publicado:	Oxford University Press 2005
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1065261/ https://www.ncbi.nlm.nih.gov/pubmed/15767286 http://dx.doi.org/10.1093/nar/gki308

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