Targeting FAcilitates Chromatin Transcription complex inhibits pleural mesothelioma and enhances immunotherapy

BACKGROUND: Diffuse pleural mesothelioma (DPM) is an aggressive therapy-resistant cancer with unique molecular features. Numerous agents have been tested, but clinically effective ones remain elusive. Herein, we propose to use a small molecule CBL0137 (curaxin) that simultaneously suppresses nuclear...

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Detalles Bibliográficos
Autores principales: Singh, Anand, Pruett, Nathanael, Dixit, Shivani, Gara, Sudheer K., Wang, Haitao, Pahwa, Roma, Schrump, David S., Hoang, Chuong D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10652639/
https://www.ncbi.nlm.nih.gov/pubmed/37974213
http://dx.doi.org/10.1186/s13046-023-02889-6

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