Neutralizing Aptamers from Whole-Cell SELEX Inhibit the RET Receptor Tyrosine Kinase

Targeting large transmembrane molecules, including receptor tyrosine kinases, is a major pharmacological challenge. Specific oligonucleotide ligands (aptamers) can be generated for a variety of targets through the iterative evolution of a random pool of sequences (SELEX). Nuclease-resistant aptamers...

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Detalles Bibliográficos
Autores principales: Cerchia, Laura, Ducongé, Frédéric, Pestourie, Carine, Boulay, Jocelyne, Aissouni, Youssef, Gombert, Karine, Tavitian, Bertrand, de Franciscis, Vittorio, Libri, Domenico
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2005
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1065267/
https://www.ncbi.nlm.nih.gov/pubmed/15769183
http://dx.doi.org/10.1371/journal.pbio.0030123

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