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En face optical coherence tomography detection of Schlemm’s canal in primary open angle glaucoma
Purpose: To compare the morphological characteristics of Schlemm’s canal (SC) in patients with primary open-angle glaucoma (POAG) and healthy controls, using swept-source optical coherence tomography (SS-OCT) with en face reconstruction. Methods: In this Prospective comparative study, we included 10...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10652746/ https://www.ncbi.nlm.nih.gov/pubmed/38028808 http://dx.doi.org/10.3389/fphys.2023.1214427 |
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author | Huang, Haili Tian, Lijia Sun, Xinghuai Chen, Yuhong |
author_facet | Huang, Haili Tian, Lijia Sun, Xinghuai Chen, Yuhong |
author_sort | Huang, Haili |
collection | PubMed |
description | Purpose: To compare the morphological characteristics of Schlemm’s canal (SC) in patients with primary open-angle glaucoma (POAG) and healthy controls, using swept-source optical coherence tomography (SS-OCT) with en face reconstruction. Methods: In this Prospective comparative study, we included 100 eyes from 50 patients diagnosed with POAG and 50 healthy controls. Three-dimensional cube and line scans of the temporal and nasal quadrants of the anterior segment of the limbus were acquired using SS-OCT. SC was identified using en face and cross-sectional images. The diameter and area of SC in cross-sectional images and the visible percentage and area of SC in en face images were measured using ImageJ. Results: SC was observed in 84% of en face images and 81% of cross-sectional images in eyes with POAG but in 92% of en face images and 86% of cross-sectional images in control eyes. Significant differences between the POAG and normal control eyes were found in the en face area (0.35 ± 0.14 mm(2) vs. 0.56 ± 0.22 mm(2) in the temporal quadrant and 0.36 ± 0.14 mm(2) vs. 0.58 ± 0.23 mm(2) in the nasal quadrant; both p < 0.001) and visible percentage of SC (85.71% vs. 94.91% and 87.10% vs. 95.52% in the temporal and nasal quadrant respectively, both p < 0.001) in en face images as well as the cross-sectional area (2790.9 ± 942.2 μm(2) vs. 4138.6 ± 2027.8 μm(2) in the temporal quadrant and 2805.7 ± 947.2 μm(2) vs. 4224.0 ± 2002.2 μm(2) in the nasal quadrant, both p < 0.001) and diameter of SC (123.1 ± 25.4 μm vs. 149.5 ± 34.7 μm in the temporal quadrant and 126.3 ± 28.9 μm vs. 155.3 ± 36.0 μm in the nasal quadrant, both p < 0.001) in cross-section images. In addition, the mean intraocular pressure (IOP) significantly correlated with the en face area, visible percentage of SC, and cross-sectional area in the temporal and nasal quadrants. Conclusion: SS-OCT can obtain high-quality en face images of SC without post-acquisition processing. Eyes with POAG had a decreased en face SC area compared with normal eyes. A correlation between SC area, visible percentage of en face images, and IOP was also observed. |
format | Online Article Text |
id | pubmed-10652746 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-106527462023-11-02 En face optical coherence tomography detection of Schlemm’s canal in primary open angle glaucoma Huang, Haili Tian, Lijia Sun, Xinghuai Chen, Yuhong Front Physiol Physiology Purpose: To compare the morphological characteristics of Schlemm’s canal (SC) in patients with primary open-angle glaucoma (POAG) and healthy controls, using swept-source optical coherence tomography (SS-OCT) with en face reconstruction. Methods: In this Prospective comparative study, we included 100 eyes from 50 patients diagnosed with POAG and 50 healthy controls. Three-dimensional cube and line scans of the temporal and nasal quadrants of the anterior segment of the limbus were acquired using SS-OCT. SC was identified using en face and cross-sectional images. The diameter and area of SC in cross-sectional images and the visible percentage and area of SC in en face images were measured using ImageJ. Results: SC was observed in 84% of en face images and 81% of cross-sectional images in eyes with POAG but in 92% of en face images and 86% of cross-sectional images in control eyes. Significant differences between the POAG and normal control eyes were found in the en face area (0.35 ± 0.14 mm(2) vs. 0.56 ± 0.22 mm(2) in the temporal quadrant and 0.36 ± 0.14 mm(2) vs. 0.58 ± 0.23 mm(2) in the nasal quadrant; both p < 0.001) and visible percentage of SC (85.71% vs. 94.91% and 87.10% vs. 95.52% in the temporal and nasal quadrant respectively, both p < 0.001) in en face images as well as the cross-sectional area (2790.9 ± 942.2 μm(2) vs. 4138.6 ± 2027.8 μm(2) in the temporal quadrant and 2805.7 ± 947.2 μm(2) vs. 4224.0 ± 2002.2 μm(2) in the nasal quadrant, both p < 0.001) and diameter of SC (123.1 ± 25.4 μm vs. 149.5 ± 34.7 μm in the temporal quadrant and 126.3 ± 28.9 μm vs. 155.3 ± 36.0 μm in the nasal quadrant, both p < 0.001) in cross-section images. In addition, the mean intraocular pressure (IOP) significantly correlated with the en face area, visible percentage of SC, and cross-sectional area in the temporal and nasal quadrants. Conclusion: SS-OCT can obtain high-quality en face images of SC without post-acquisition processing. Eyes with POAG had a decreased en face SC area compared with normal eyes. A correlation between SC area, visible percentage of en face images, and IOP was also observed. Frontiers Media S.A. 2023-11-02 /pmc/articles/PMC10652746/ /pubmed/38028808 http://dx.doi.org/10.3389/fphys.2023.1214427 Text en Copyright © 2023 Huang, Tian, Sun and Chen. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Physiology Huang, Haili Tian, Lijia Sun, Xinghuai Chen, Yuhong En face optical coherence tomography detection of Schlemm’s canal in primary open angle glaucoma |
title |
En face optical coherence tomography detection of Schlemm’s canal in primary open angle glaucoma |
title_full |
En face optical coherence tomography detection of Schlemm’s canal in primary open angle glaucoma |
title_fullStr |
En face optical coherence tomography detection of Schlemm’s canal in primary open angle glaucoma |
title_full_unstemmed |
En face optical coherence tomography detection of Schlemm’s canal in primary open angle glaucoma |
title_short |
En face optical coherence tomography detection of Schlemm’s canal in primary open angle glaucoma |
title_sort | en face optical coherence tomography detection of schlemm’s canal in primary open angle glaucoma |
topic | Physiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10652746/ https://www.ncbi.nlm.nih.gov/pubmed/38028808 http://dx.doi.org/10.3389/fphys.2023.1214427 |
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