Myt1 overexpression mediates resistance to cell cycle and DNA damage checkpoint kinase inhibitors

Cell cycle checkpoint kinases serve as important therapeutic targets for various cancers. When they are inhibited by small molecules, checkpoint abrogation can induce cell death or further sensitize cancer cells to other genotoxic therapies. Particularly aberrant Cdk1 activation at the G2/M checkpoi...

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Detalles Bibliográficos
Autores principales: Sokhi, Sargun, Lewis, Cody W., Bukhari, Amirali B., Hadfield, Joanne, Xiao, Edric J., Fung, Jeremy, Yoon, Yea Jin, Hsu, Wen-Hsin, Gamper, Armin M., Chan, Gordon K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10652759/
https://www.ncbi.nlm.nih.gov/pubmed/38020882
http://dx.doi.org/10.3389/fcell.2023.1270542

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