A self-amplifying RNA vaccine provides protection in a murine model of bubonic plague

Mice were immunized with a combination of self-amplifying (sa) RNA constructs for the F1 and V antigens of Yersinia pestis at a dose level of 1 μg or 5 μg or with the respective protein sub-units as a reference vaccine. The immunization of outbred OF1 mice on day 0 and day 28 with the lowest dose us...

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Detalles Bibliográficos
Autores principales: Shattock, Robin John, Andrianaivoarimanana, Voahangy, McKay, Paul F., Randriantseheno, Lovasoa Nomena, Murugaiah, Valarmathy, Samnuan, K., Rogers, Paul, Tregoning, John S., Rajerison, Minoarisoa, Moore, Kristoffer M., Laws, Thomas Robert, Williamson, E. Diane
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10652872/
https://www.ncbi.nlm.nih.gov/pubmed/38029221
http://dx.doi.org/10.3389/fmicb.2023.1247041

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