T7 expression plasmids for producing a recombinant human G1P[8] rotavirus comprising RIX4414 sequences of the RV1 (Rotarix , GSK) vaccine strain

The live oral rotavirus RV1 (Rotarix) vaccine is formulated from the human G1P[8] RIX4414 virus. Based on RIX4414 sequences, T7 expression plasmids were constructed that supported recovery of recombinant RIX4414-like viruses by reverse genetics. These plasmids will advance the study of the RV1 vacci...

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Autores principales: Philip, Asha A., Agbemabiese, Chantal A., Yi, Guanghui, Patton, John T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2023
Materias:
Other Genetic Resources
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10652971/
https://www.ncbi.nlm.nih.gov/pubmed/37819123
http://dx.doi.org/10.1128/MRA.00603-23
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author Philip, Asha A.
Agbemabiese, Chantal A.
Yi, Guanghui
Patton, John T.
author_facet Philip, Asha A.
Agbemabiese, Chantal A.
Yi, Guanghui
Patton, John T.
author_sort Philip, Asha A.
collection PubMed
description The live oral rotavirus RV1 (Rotarix) vaccine is formulated from the human G1P[8] RIX4414 virus. Based on RIX4414 sequences, T7 expression plasmids were constructed that supported recovery of recombinant RIX4414-like viruses by reverse genetics. These plasmids will advance the study of the RV1 vaccine, possibly allowing improvements to its efficacy.
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spelling pubmed-106529712023-10-11 T7 expression plasmids for producing a recombinant human G1P[8] rotavirus comprising RIX4414 sequences of the RV1 (Rotarix , GSK) vaccine strain Philip, Asha A. Agbemabiese, Chantal A. Yi, Guanghui Patton, John T. Microbiol Resour Announc Other Genetic Resources The live oral rotavirus RV1 (Rotarix) vaccine is formulated from the human G1P[8] RIX4414 virus. Based on RIX4414 sequences, T7 expression plasmids were constructed that supported recovery of recombinant RIX4414-like viruses by reverse genetics. These plasmids will advance the study of the RV1 vaccine, possibly allowing improvements to its efficacy. American Society for Microbiology 2023-10-11 /pmc/articles/PMC10652971/ /pubmed/37819123 http://dx.doi.org/10.1128/MRA.00603-23 Text en Copyright © 2023 Philip et al. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Other Genetic Resources
Philip, Asha A.
Agbemabiese, Chantal A.
Yi, Guanghui
Patton, John T.
T7 expression plasmids for producing a recombinant human G1P[8] rotavirus comprising RIX4414 sequences of the RV1 (Rotarix , GSK) vaccine strain
title T7 expression plasmids for producing a recombinant human G1P[8] rotavirus comprising RIX4414 sequences of the RV1 (Rotarix , GSK) vaccine strain
title_full T7 expression plasmids for producing a recombinant human G1P[8] rotavirus comprising RIX4414 sequences of the RV1 (Rotarix , GSK) vaccine strain
title_fullStr T7 expression plasmids for producing a recombinant human G1P[8] rotavirus comprising RIX4414 sequences of the RV1 (Rotarix , GSK) vaccine strain
title_full_unstemmed T7 expression plasmids for producing a recombinant human G1P[8] rotavirus comprising RIX4414 sequences of the RV1 (Rotarix , GSK) vaccine strain
title_short T7 expression plasmids for producing a recombinant human G1P[8] rotavirus comprising RIX4414 sequences of the RV1 (Rotarix , GSK) vaccine strain
title_sort t7 expression plasmids for producing a recombinant human g1p[8] rotavirus comprising rix4414 sequences of the rv1 (rotarix , gsk) vaccine strain
topic Other Genetic Resources
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10652971/
https://www.ncbi.nlm.nih.gov/pubmed/37819123
http://dx.doi.org/10.1128/MRA.00603-23
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