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Loss of COP9 signalosome genes at 2q37 is associated with IMiD resistance in multiple myeloma

The acquisition of a multidrug refractory state is a major cause of mortality in myeloma. Myeloma drugs that target the cereblon (CRBN) protein include widely used immunomodulatory drugs (IMiDs), and newer CRBN E3 ligase modulator drugs (CELMoDs), in clinical trials. CRBN genetic disruption causes r...

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Detalles Bibliográficos
Autores principales:	Gooding, Sarah, Ansari-Pour, Naser, Kazeroun, Mohammad, Karagoz, Kubra, Polonskaia, Ann, Salazar, Mirian, Fitzsimons, Evie, Sirinukunwattana, Korsuk, Chavda, Selina, Ortiz Estevez, Maria, Towfic, Fadi, Flynt, Erin, Pierceall, William, Royston, Daniel, Yong, Kwee, Ramasamy, Karthik, Vyas, Paresh, Thakurta, Anjan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The American Society of Hematology 2022
Materias:	Lymphoid Neoplasia
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10653034/ https://www.ncbi.nlm.nih.gov/pubmed/35853156 http://dx.doi.org/10.1182/blood.2022015909

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