Design, Synthesis, Molecular Modeling, Biological Activity, and Mechanism of Action of Novel Amino Acid Derivatives of Norfloxacin

[Image: see text] Two series of N4-substituted piperazinyl amino acid derivatives of norfloxacin (24 new compounds) were designed and synthesized to attain structural surrogates with additional binding sites and enhanced antibacterial activity. Synthesized derivatives showed increased antibacterial...

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Detalles Bibliográficos
Autores principales: Kamal El-sagheir, Ahmed M., Abdelmesseh Nekhala, Ireny, Abd El-Gaber, Mohammed K., Aboraia, Ahmed S., Persson, Jonatan, Schäfer, Ann-Britt, Wenzel, Michaela, Omar, Farghaly A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10653056/
https://www.ncbi.nlm.nih.gov/pubmed/38024743
http://dx.doi.org/10.1021/acsomega.3c07221

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10653056/
https://www.ncbi.nlm.nih.gov/pubmed/38024743
http://dx.doi.org/10.1021/acsomega.3c07221

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