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Minimal information for reporting a genomics experiment

Exome and genome sequencing has facilitated the identification of hundreds of genes and other regions that are recurrently mutated in hematologic neoplasms. The data sets from these studies theoretically provide opportunities. Quality differences between data sets can confound secondary analyses. We...

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Detalles Bibliográficos
Autores principales: Dreval, Kostiantyn, Boutros, Paul C., Morin, Ryan D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society of Hematology 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10653092/
https://www.ncbi.nlm.nih.gov/pubmed/36219881
http://dx.doi.org/10.1182/blood.2022016095
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author Dreval, Kostiantyn
Boutros, Paul C.
Morin, Ryan D.
author_facet Dreval, Kostiantyn
Boutros, Paul C.
Morin, Ryan D.
author_sort Dreval, Kostiantyn
collection PubMed
description Exome and genome sequencing has facilitated the identification of hundreds of genes and other regions that are recurrently mutated in hematologic neoplasms. The data sets from these studies theoretically provide opportunities. Quality differences between data sets can confound secondary analyses. We explore the consequences of these on the conclusions from some recent studies of B-cell lymphomas. We highlight the need for a minimum reporting standard to increase transparency in genomic research.
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spelling pubmed-106530922022-10-14 Minimal information for reporting a genomics experiment Dreval, Kostiantyn Boutros, Paul C. Morin, Ryan D. Blood Blood Spotlight Exome and genome sequencing has facilitated the identification of hundreds of genes and other regions that are recurrently mutated in hematologic neoplasms. The data sets from these studies theoretically provide opportunities. Quality differences between data sets can confound secondary analyses. We explore the consequences of these on the conclusions from some recent studies of B-cell lymphomas. We highlight the need for a minimum reporting standard to increase transparency in genomic research. The American Society of Hematology 2022-12-15 2022-10-14 /pmc/articles/PMC10653092/ /pubmed/36219881 http://dx.doi.org/10.1182/blood.2022016095 Text en © 2022 by The American Society of Hematology. Licensed under Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0), permitting only noncommercial, nonderivative use with attribution. All other rights reserved. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Blood Spotlight
Dreval, Kostiantyn
Boutros, Paul C.
Morin, Ryan D.
Minimal information for reporting a genomics experiment
title Minimal information for reporting a genomics experiment
title_full Minimal information for reporting a genomics experiment
title_fullStr Minimal information for reporting a genomics experiment
title_full_unstemmed Minimal information for reporting a genomics experiment
title_short Minimal information for reporting a genomics experiment
title_sort minimal information for reporting a genomics experiment
topic Blood Spotlight
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10653092/
https://www.ncbi.nlm.nih.gov/pubmed/36219881
http://dx.doi.org/10.1182/blood.2022016095
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