Enterocutaneous Fistula in a COVID-19 Obese Patient During Prolonged Prone Position for Severe Acute Respiratory Distress Syndrome

Prone position (PP) has been widely used in patients under mechanical ventilation for COVID-19 acute respiratory distress syndrome (ARDS), usually for many hours per day. Complications are not rare, although most of them are mild. To our knowledge, we report the first case of enterocutaneous fistula after prolonged use of PP in the literature. Morbid obesity; yielding increased abdominal wall pressure when the patient was prone; pre-existing intestinal hernias; and increased vasopressor doses for septic shock due to secondary infections resulted in necrosis of the small intestine, the abdominal wall, and the skin leading to enterocutaneous fistula. Clinicians managing patients with COVID-19 should keep in mind this complication, especially when proning obese patients with a history of intestinal surgery, as the presence of intestinal hernias might be missed during a clinical examination.