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Computational exploration of novel ROCK2 inhibitors for cardiovascular disease management; insights from high-throughput virtual screening, molecular docking, DFT and MD simulation

Cardiovascular disorders are the world’s major cause of death nowadays. To treat cardiovascular diseases especially coronary artery diseases and hypertension, researchers found potential ROCK2 (Rho-associated coiled-coil-containing protein kinase 2) target due to its substantial role in NO-cGMP and...

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Detalles Bibliográficos
Autores principales:	Ali, Iqra, Iqbal, Muhammad Nasir, Ibrahim, Muhammad, Haq, Ihtisham Ul, Alonazi, Wadi B., Siddiqi, Abdul Rauf
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10653426/ https://www.ncbi.nlm.nih.gov/pubmed/37972144 http://dx.doi.org/10.1371/journal.pone.0294511

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