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Predictive value of serum creatinine and total bilirubin for long-term death in patients with ischemic heart disease: A cohort study
BACKGROUND: Ischemic heart disease (IHD) has a high mortality in the population. Although serum creatinine (Cr) and serum total bilirubin (TBil) are rapid and readily available biomarkers in routine blood tests, there is a lack of literature on the prognostic value of combined Cr and TBil tests for...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10653523/ https://www.ncbi.nlm.nih.gov/pubmed/37971981 http://dx.doi.org/10.1371/journal.pone.0294335 |
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author | Seyiti, Zulihuma Yang, Long Kasimujiang, Abudushalamu Dejite, Tuohutasheng Shan, Xue-Feng Gao, Xiao-Ming |
author_facet | Seyiti, Zulihuma Yang, Long Kasimujiang, Abudushalamu Dejite, Tuohutasheng Shan, Xue-Feng Gao, Xiao-Ming |
author_sort | Seyiti, Zulihuma |
collection | PubMed |
description | BACKGROUND: Ischemic heart disease (IHD) has a high mortality in the population. Although serum creatinine (Cr) and serum total bilirubin (TBil) are rapid and readily available biomarkers in routine blood tests, there is a lack of literature on the prognostic value of combined Cr and TBil tests for IHD. This study aimed to evaluate a combined equation based on Cr and TBil to predict the long-term risk of death in IHD and to find indicators sensitive to the prognosis of IHD patients. METHOD: In this study, 2625 patients with IHD were included, and the combined value and combined equations of Cr and TBil were obtained by logistic regression analysis based on Cr and TBil collected at the time of admission. Patients were divided into four groups according to the quartiles of the combined value. COX proportional hazard regression model was used to analyze the risk factors for long-term death in IHD patients. Receiver operating characteristic (ROC) curves were used to evaluate the prognostic effect of Cr, TBil and combined value on long-term death events. RESULTS: Logistic regression analysis was performed for long-term death events with Cr and TBil as independent variables, and the logit regression model was Logit(P) = 0.0129×TBil+0.007×Cr-0.417. Multifactorial Cox regression analysis showed that high values of the equation were independent risk factors for long-term death events (all-cause death: HR 1.457, 95% CI 1.256–1.689, P<0.001; cardiovascular death: HR 1.452, 95% CI 1.244–1.695, P<0.001). Combined Cr and TBil value are more valuable in predicting long-term death (AUC: 0.609, 95% CI 0.587–0.630, P<0.001). CONCLUSION: Combined Cr and TBil assay is superior to single biomarkers for predicting long-term death in patients with IHD. High values of the equation are independent predictors of long-term death and can be used to identify patients at high risk for IHD. |
format | Online Article Text |
id | pubmed-10653523 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-106535232023-11-16 Predictive value of serum creatinine and total bilirubin for long-term death in patients with ischemic heart disease: A cohort study Seyiti, Zulihuma Yang, Long Kasimujiang, Abudushalamu Dejite, Tuohutasheng Shan, Xue-Feng Gao, Xiao-Ming PLoS One Research Article BACKGROUND: Ischemic heart disease (IHD) has a high mortality in the population. Although serum creatinine (Cr) and serum total bilirubin (TBil) are rapid and readily available biomarkers in routine blood tests, there is a lack of literature on the prognostic value of combined Cr and TBil tests for IHD. This study aimed to evaluate a combined equation based on Cr and TBil to predict the long-term risk of death in IHD and to find indicators sensitive to the prognosis of IHD patients. METHOD: In this study, 2625 patients with IHD were included, and the combined value and combined equations of Cr and TBil were obtained by logistic regression analysis based on Cr and TBil collected at the time of admission. Patients were divided into four groups according to the quartiles of the combined value. COX proportional hazard regression model was used to analyze the risk factors for long-term death in IHD patients. Receiver operating characteristic (ROC) curves were used to evaluate the prognostic effect of Cr, TBil and combined value on long-term death events. RESULTS: Logistic regression analysis was performed for long-term death events with Cr and TBil as independent variables, and the logit regression model was Logit(P) = 0.0129×TBil+0.007×Cr-0.417. Multifactorial Cox regression analysis showed that high values of the equation were independent risk factors for long-term death events (all-cause death: HR 1.457, 95% CI 1.256–1.689, P<0.001; cardiovascular death: HR 1.452, 95% CI 1.244–1.695, P<0.001). Combined Cr and TBil value are more valuable in predicting long-term death (AUC: 0.609, 95% CI 0.587–0.630, P<0.001). CONCLUSION: Combined Cr and TBil assay is superior to single biomarkers for predicting long-term death in patients with IHD. High values of the equation are independent predictors of long-term death and can be used to identify patients at high risk for IHD. Public Library of Science 2023-11-16 /pmc/articles/PMC10653523/ /pubmed/37971981 http://dx.doi.org/10.1371/journal.pone.0294335 Text en © 2023 Seyiti et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Seyiti, Zulihuma Yang, Long Kasimujiang, Abudushalamu Dejite, Tuohutasheng Shan, Xue-Feng Gao, Xiao-Ming Predictive value of serum creatinine and total bilirubin for long-term death in patients with ischemic heart disease: A cohort study |
title | Predictive value of serum creatinine and total bilirubin for long-term death in patients with ischemic heart disease: A cohort study |
title_full | Predictive value of serum creatinine and total bilirubin for long-term death in patients with ischemic heart disease: A cohort study |
title_fullStr | Predictive value of serum creatinine and total bilirubin for long-term death in patients with ischemic heart disease: A cohort study |
title_full_unstemmed | Predictive value of serum creatinine and total bilirubin for long-term death in patients with ischemic heart disease: A cohort study |
title_short | Predictive value of serum creatinine and total bilirubin for long-term death in patients with ischemic heart disease: A cohort study |
title_sort | predictive value of serum creatinine and total bilirubin for long-term death in patients with ischemic heart disease: a cohort study |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10653523/ https://www.ncbi.nlm.nih.gov/pubmed/37971981 http://dx.doi.org/10.1371/journal.pone.0294335 |
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