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Influence of cardiovascular risk factors and treatment exposure on cardiovascular event incidence: Assessment using machine learning algorithms

Assessment of the influence of cardiovascular risk factors (CVRF) on cardiovascular event (CVE) using machine learning algorithms offers some advantages over preexisting scoring systems, and better enables personalized medicine approaches to cardiovascular prevention. Using data from four different...

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Autores principales: Castel-Feced, Sara, Malo, Sara, Aguilar-Palacio, Isabel, Feja-Solana, Cristina, Casasnovas, José Antonio, Maldonado, Lina, Rabanaque-Hernández, María José
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10653526/
https://www.ncbi.nlm.nih.gov/pubmed/37971977
http://dx.doi.org/10.1371/journal.pone.0293759
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author Castel-Feced, Sara
Malo, Sara
Aguilar-Palacio, Isabel
Feja-Solana, Cristina
Casasnovas, José Antonio
Maldonado, Lina
Rabanaque-Hernández, María José
author_facet Castel-Feced, Sara
Malo, Sara
Aguilar-Palacio, Isabel
Feja-Solana, Cristina
Casasnovas, José Antonio
Maldonado, Lina
Rabanaque-Hernández, María José
author_sort Castel-Feced, Sara
collection PubMed
description Assessment of the influence of cardiovascular risk factors (CVRF) on cardiovascular event (CVE) using machine learning algorithms offers some advantages over preexisting scoring systems, and better enables personalized medicine approaches to cardiovascular prevention. Using data from four different sources, we evaluated the outcomes of three machine learning algorithms for CVE prediction using different combinations of predictive variables and analysed the influence of different CVRF-related variables on CVE prediction when included in these algorithms. A cohort study based on a male cohort of workers applying populational data was conducted. The population of the study consisted of 3746 males. For descriptive analyses, mean and standard deviation were used for quantitative variables, and percentages for categorical ones. Machine learning algorithms used were XGBoost, Random Forest and Naïve Bayes (NB). They were applied to two groups of variables: i) age, physical status, Hypercholesterolemia (HC), Hypertension, and Diabetes Mellitus (DM) and ii) these variables plus treatment exposure, based on the adherence to the treatment for DM, hypertension and HC. All methods point out to the age as the most influential variable in the incidence of a CVE. When considering treatment exposure, it was more influential than any other CVRF, which changed its influence depending on the model and algorithm applied. According to the performance of the algorithms, the most accurate was Random Forest when treatment exposure was considered (F1 score 0.84), followed by XGBoost. Adherence to treatment showed to be an important variable in the risk of having a CVE. These algorithms could be applied to create models for every population, and they can be used in primary care to manage interventions personalized for every subject.
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spelling pubmed-106535262023-11-16 Influence of cardiovascular risk factors and treatment exposure on cardiovascular event incidence: Assessment using machine learning algorithms Castel-Feced, Sara Malo, Sara Aguilar-Palacio, Isabel Feja-Solana, Cristina Casasnovas, José Antonio Maldonado, Lina Rabanaque-Hernández, María José PLoS One Research Article Assessment of the influence of cardiovascular risk factors (CVRF) on cardiovascular event (CVE) using machine learning algorithms offers some advantages over preexisting scoring systems, and better enables personalized medicine approaches to cardiovascular prevention. Using data from four different sources, we evaluated the outcomes of three machine learning algorithms for CVE prediction using different combinations of predictive variables and analysed the influence of different CVRF-related variables on CVE prediction when included in these algorithms. A cohort study based on a male cohort of workers applying populational data was conducted. The population of the study consisted of 3746 males. For descriptive analyses, mean and standard deviation were used for quantitative variables, and percentages for categorical ones. Machine learning algorithms used were XGBoost, Random Forest and Naïve Bayes (NB). They were applied to two groups of variables: i) age, physical status, Hypercholesterolemia (HC), Hypertension, and Diabetes Mellitus (DM) and ii) these variables plus treatment exposure, based on the adherence to the treatment for DM, hypertension and HC. All methods point out to the age as the most influential variable in the incidence of a CVE. When considering treatment exposure, it was more influential than any other CVRF, which changed its influence depending on the model and algorithm applied. According to the performance of the algorithms, the most accurate was Random Forest when treatment exposure was considered (F1 score 0.84), followed by XGBoost. Adherence to treatment showed to be an important variable in the risk of having a CVE. These algorithms could be applied to create models for every population, and they can be used in primary care to manage interventions personalized for every subject. Public Library of Science 2023-11-16 /pmc/articles/PMC10653526/ /pubmed/37971977 http://dx.doi.org/10.1371/journal.pone.0293759 Text en © 2023 Castel-Feced et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Castel-Feced, Sara
Malo, Sara
Aguilar-Palacio, Isabel
Feja-Solana, Cristina
Casasnovas, José Antonio
Maldonado, Lina
Rabanaque-Hernández, María José
Influence of cardiovascular risk factors and treatment exposure on cardiovascular event incidence: Assessment using machine learning algorithms
title Influence of cardiovascular risk factors and treatment exposure on cardiovascular event incidence: Assessment using machine learning algorithms
title_full Influence of cardiovascular risk factors and treatment exposure on cardiovascular event incidence: Assessment using machine learning algorithms
title_fullStr Influence of cardiovascular risk factors and treatment exposure on cardiovascular event incidence: Assessment using machine learning algorithms
title_full_unstemmed Influence of cardiovascular risk factors and treatment exposure on cardiovascular event incidence: Assessment using machine learning algorithms
title_short Influence of cardiovascular risk factors and treatment exposure on cardiovascular event incidence: Assessment using machine learning algorithms
title_sort influence of cardiovascular risk factors and treatment exposure on cardiovascular event incidence: assessment using machine learning algorithms
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10653526/
https://www.ncbi.nlm.nih.gov/pubmed/37971977
http://dx.doi.org/10.1371/journal.pone.0293759
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