Effect of the interval between birth and second dose of hepatitis B vaccine on perinatal transmission of hepatitis B virus

Preventing perinatal transmission is important for hepatitis B (HepB) elimination. We conducted a retrospective cohort study to assess the interval between HepB birth-dose (HepB-BD) to second-dose (HepB-SD) vaccination on perinatal transmission. Among 39,313 infants born to HepB s-antigen (HBsAg)-po...

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Autores principales: Yang, Tae Un, Vargas-Zambrano, Juan C., Park, Hang A, Jung, Chae Won, Kim, Dongwook, Jee, Youngmee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2023
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10653619/
https://www.ncbi.nlm.nih.gov/pubmed/37955105
http://dx.doi.org/10.1080/21645515.2023.2278940
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author Yang, Tae Un
Vargas-Zambrano, Juan C.
Park, Hang A
Jung, Chae Won
Kim, Dongwook
Jee, Youngmee
author_facet Yang, Tae Un
Vargas-Zambrano, Juan C.
Park, Hang A
Jung, Chae Won
Kim, Dongwook
Jee, Youngmee
author_sort Yang, Tae Un
collection PubMed
description Preventing perinatal transmission is important for hepatitis B (HepB) elimination. We conducted a retrospective cohort study to assess the interval between HepB birth-dose (HepB-BD) to second-dose (HepB-SD) vaccination on perinatal transmission. Among 39,313 infants born to HepB s-antigen (HBsAg)-positive mothers from a Korean national database 38,411 (97.7%) had completed timely immunophylaxis with HepB-BD 41,572 (99.8%) with hepatitis B immune globulin, and 1027 (2.6%) were HBsAg-positive at ≥ 9 months. Maternal factors (i.e. HepB e-antigen status, age, or nationality) were associated with an increased risk of infection whereas short gestational length decreased it. The HepB-BD – HepB-SD interval (<8 vs. ≥8 weeks) did not alter the risk.
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spelling pubmed-106536192023-11-13 Effect of the interval between birth and second dose of hepatitis B vaccine on perinatal transmission of hepatitis B virus Yang, Tae Un Vargas-Zambrano, Juan C. Park, Hang A Jung, Chae Won Kim, Dongwook Jee, Youngmee Hum Vaccin Immunother Brief Report Preventing perinatal transmission is important for hepatitis B (HepB) elimination. We conducted a retrospective cohort study to assess the interval between HepB birth-dose (HepB-BD) to second-dose (HepB-SD) vaccination on perinatal transmission. Among 39,313 infants born to HepB s-antigen (HBsAg)-positive mothers from a Korean national database 38,411 (97.7%) had completed timely immunophylaxis with HepB-BD 41,572 (99.8%) with hepatitis B immune globulin, and 1027 (2.6%) were HBsAg-positive at ≥ 9 months. Maternal factors (i.e. HepB e-antigen status, age, or nationality) were associated with an increased risk of infection whereas short gestational length decreased it. The HepB-BD – HepB-SD interval (<8 vs. ≥8 weeks) did not alter the risk. Taylor & Francis 2023-11-13 /pmc/articles/PMC10653619/ /pubmed/37955105 http://dx.doi.org/10.1080/21645515.2023.2278940 Text en © 2023 The Author(s). Published with license by Taylor & Francis Group, LLC. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent.
spellingShingle Brief Report
Yang, Tae Un
Vargas-Zambrano, Juan C.
Park, Hang A
Jung, Chae Won
Kim, Dongwook
Jee, Youngmee
Effect of the interval between birth and second dose of hepatitis B vaccine on perinatal transmission of hepatitis B virus
title Effect of the interval between birth and second dose of hepatitis B vaccine on perinatal transmission of hepatitis B virus
title_full Effect of the interval between birth and second dose of hepatitis B vaccine on perinatal transmission of hepatitis B virus
title_fullStr Effect of the interval between birth and second dose of hepatitis B vaccine on perinatal transmission of hepatitis B virus
title_full_unstemmed Effect of the interval between birth and second dose of hepatitis B vaccine on perinatal transmission of hepatitis B virus
title_short Effect of the interval between birth and second dose of hepatitis B vaccine on perinatal transmission of hepatitis B virus
title_sort effect of the interval between birth and second dose of hepatitis b vaccine on perinatal transmission of hepatitis b virus
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10653619/
https://www.ncbi.nlm.nih.gov/pubmed/37955105
http://dx.doi.org/10.1080/21645515.2023.2278940
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