A novel N-heterocycles substituted oseltamivir derivatives as potent inhibitors of influenza virus neuraminidase: discovery, synthesis and biological evaluation

Our previous studies have shown that the introduction of structurally diverse benzyl side chains at the C5-NH(2) position of oseltamivir to occupy 150-cavity contributes to the binding affinity with neuraminidase and anti-influenza activity. To obtain broad-spectrum neuraminidase inhibitors, we desi...

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Detalles Bibliográficos
Autores principales: Zhang, Jiwei, Liu, Chuanfeng, Jia, Ruifang, Zhang, Xujie, Zhang, Jian, Bertagnin, Chiara, Bonomini, Anna, Guizzo, Laura, Jiang, Yuanmin, Jia, Huinan, Jia, Shuzhen, Ma, Xiuli, Loregian, Arianna, Huang, Bing, Zhan, Peng, Liu, Xinyong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10653643/
https://www.ncbi.nlm.nih.gov/pubmed/37955306
http://dx.doi.org/10.1080/14756366.2023.2277135

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