Novel harmine derivatives as potent acetylcholinesterase and amyloid beta aggregation dual inhibitors for management of Alzheimer’s disease

In this study, a series of potential ligands for the treatment of AD were synthesised and characterised as novel harmine derivatives modified at position 9 with benzyl piperazinyl. In vitro studies revealed that the majority of the derivatives exhibited moderate to potent inhibition against hAChE an...

Descripción completa

Detalles Bibliográficos
Autores principales: Du, Hongtao, Song, Jinzhi, Ma, Fang, Gao, Hongxin, Zhao, Xinyan, Mao, Renjun, He, Xiaolong, Yan, Yan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10653770/
https://www.ncbi.nlm.nih.gov/pubmed/37965884
http://dx.doi.org/10.1080/14756366.2023.2281893

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10653770/
https://www.ncbi.nlm.nih.gov/pubmed/37965884
http://dx.doi.org/10.1080/14756366.2023.2281893

Ejemplares similares