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Assembling the anaerobic gamma-butyrobetaine to TMA metabolic pathway in Escherichia fergusonii and confirming its role in TMA production from dietary L-carnitine in murine models

Trimethylamine-N-oxide (TMAO) is a major pro-atherogenic and pro-thrombotic metaorganismal molecule produced through the initial conversion of the dietary L-carnitine and other precursors into trimethylamine (TMA). We recently identified a dual-microbe anaerobic pathway for the metabolism of L-carni...

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Detalles Bibliográficos
Autores principales:	Dwidar, Mohammed, Buffa, Jennifer A., Wang, Zeneng, Santos, Akeem, Tittle, Aaron N., Fu, Xiaoming, Hajjar, Adeline M., DiDonato, Joseph A., Hazen, Stanley L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2023
Materias:	Observation
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10653785/ https://www.ncbi.nlm.nih.gov/pubmed/37737636 http://dx.doi.org/10.1128/mbio.00937-23

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