Gene editing of SAMHD1 in macrophage-like cells reveals complex relationships between SAMHD1 phospho-regulation, HIV-1 restriction, and cellular dNTP levels

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Sterile α motif and HD domain-containing protein 1 (SAMHD1) is a dNTP triphosphate triphosphohydrolase (dNTPase) and a potent restriction factor for immunodeficiency virus 1 (HIV-1), active in myeloid and resting CD4(+) T cells. The anti-viral activity of SAMHD1 is regulated by dephosphorylation of...

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Detalles Bibliográficos
Autores principales: Schüssler, Moritz, Schott, Kerstin, Fuchs, Nina Verena, Oo, Adrian, Zahadi, Morssal, Rauch, Paula, Kim, Baek, König, Renate
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10653793/
https://www.ncbi.nlm.nih.gov/pubmed/37800914
http://dx.doi.org/10.1128/mbio.02252-23

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