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MicroRNA-25/93 induction by Vpu as a mechanism for counteracting MARCH1-restriction on HIV-1 infectivity in macrophages

The type 1 interferon-regulated E3 ubiquitin ligase MARCH1 reduces surface expression of HIV-1 envelope glycoproteins (Env) and their packaging into nascent virions, a condition that restricts viral infectivity. However, how HIV-1 counters this restriction, notably during infection of macrophages, r...

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Detalles Bibliográficos
Autores principales:	Lodge, Robert, Xu, Zaikun, Eklund, Mckenna, Stürzel, Christina, Kirchhoff, Frank, Tremblay, Michel J., Hobman, Tom C., Cohen, Éric A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10653795/ https://www.ncbi.nlm.nih.gov/pubmed/37773002 http://dx.doi.org/10.1128/mbio.01950-23

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