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Enhanced fungal specificity and in vivo therapeutic efficacy of a C-22-modified FK520 analog against C. neoformans

Fungal infections are of mounting global concern, and the current limited treatment arsenal poses challenges when treating such infections. In particular, infections by Cryptococcus neoformans are associated with high mortality, emphasizing the need for novel therapeutic options. Calcineurin is a pr...

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Detalles Bibliográficos
Autores principales:	Rivera, Angela, Young Lim, Won, Park, Eunchong, Dome, Patrick A., Hoy, Michael J., Spasojevic, Ivan, Sun, Sheng, Averette, Anna Floyd, Pina-Oviedo, Sergio, Juvvadi, Praveen R., Steinbach, William J., Ciofani, Maria, Hong, Jiyong, Heitman, Joseph
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10653846/ https://www.ncbi.nlm.nih.gov/pubmed/37737622 http://dx.doi.org/10.1128/mbio.01810-23

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